| PhD, 1992 | | College of Basic Sciences, H.A.U. Hissar |
| MSc | | Kurukshetra University |
| Overseas Training | | Post-Doctoral Fellow
Medical College of Wisconsin
Milwaukee, USA |
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Experience | |
- Senior Research Officer, Advanced Center for Liver Diseases, G.B. Pant Hospital, New Delhi
- Research Officer, Advanced Center for Liver Diseases, G.B. Pant Hospital, New Delhi
- DST Young Scientist, National Institute of Immunology, Neuroimmunology-1, New Delhi
- Post-Doctoral Fellow, The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin USA
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| Joined ILBS | | August, 2008 |
Area of expertise and research interest
- Regulatory parameters influencing outcome of immune response
- Mechanisms and different cellular phenotypes of innate and adaptive immunity in disease clearance or disease progression
- Phenotypic analysis of Natural killer cells, plasmacytoid, myeloid dendritic cells, and regulatory T cells in chronic infected patients
- Mechanism of pathogen interference with the functioning of the various components of the host, in order to ensure its survival
- Signaling network in controlling different phases of disease pathogenesis after HBV and HCV infection
- Receptor-mediated Notch signaling in liver, lymphocytes and in liver infiltrated lymphocytes
- Differential gene expression and their mRNA expression and protein expression in acute and chronic stages of disease pathogenesis
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| Publications | | 24 |
Representative publications
- Nirupma TrehanPati, Robert Geffers, Sukriti, Syed Hissar, Peggy Riese, Manoj Kumar ,Tanja Toepfer, Jan Buer, Carlos A. Guzman, Shiv Kumar Sarin. 2009. Gene expression signatures of peripheral CD4+T cells clearly discriminate patients with acute and chronic HBV viral infection. Hepatology. 2009 Mar;49(3):781-90.
- Sukriti , Nirupma TrehanPati, Ankur Sethi , Kireet Agrawal, Kamal Agrawal, G.T. Kumar, Manoj Kumar, A.T Kaanan, Shiv Kumar Sarin. 2008. Low levels of awareness, vaccine coverage and need for booster among health care workers in tertiary care hospitals in India. J Gastroenterol Hepatol. 2008 Nov;23(11):1710-5
- Nirupma TrehanPati, Sukriti, Syed Hissar, Kamal Agrawal, Rajni Rani, Shiv Kumar Sarin. 2006. Decrease in CD4+ T Lymphocyte proliferation responses and enhanced CD150 cell expression in health care workers non-responsive to HBV vaccine. Vaccine. 2007 Feb 26; 25(10):1848-55. Epub 2006 Nov 10.
- Pati N, Sarin S K. 2007. Hepatitis B Infection and its management by immunotherapy. Annual review book of Ranbaxy.
- Thakur V, Nirupma TrehanPati, Guptan R C, Sarin S K. 2007. The efficacy of Shanvac-B recombinant DNA hepatitis B vaccine in health care workers of Northern India. Hepatobiliary Pancreat Dis Int, Vol 6, No 3, June 15, 2007.
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Awards
- Invited Visit to the National Institute of Health, Maryland, USA, Innate Immunology Laboratory for one month from 5st Nov to 5th Dec, 2008.
- Invited Visit to the National Institute of Health, Maryland, USA, Innate Immunology Laboratory for one month from 1st Nov to 29th Nov, 2007.
- Travel Grant Award from Liver Care Foundation for attending APASL Japan, 2007.
- Invited visit to The University of Birmingham, Liver Research Group, Division of Medical Sciences, Birmhingam, from 15th April to 7th May, 2006.
- Bill and Millinda Travel Grant Award for the Ninth Annual Conference of Vaccine Research, Baltimore USA 11th May 2006.
- Travel Grant award to attend the meeting on HIV and Liver Diseases, Wyoming, 11th -14th Sep, 2006.
- Invited visit to German Research Center for biotechnology, Braunschweig, Germany for a month and half 1st sep to 10 Oct 2005.
- Best Poster Award in Indian society of Gastroenterology, Nov 2005
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Research Grants
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"Role of T cells and Dendritic cells in Type 1 diabetes mellitus (T1DM)" funded by Department of Science and Technology, Government of India, New Delhi, India. 2004-2007.
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"Therapeutic role of specific CD4/CD8 responses during sequential Therapy using Tenofovir followed by PEG- interferon to Monotherapy with Tenofovir in Chronic Hepatitis B Patients" funded by Department of Biotechnology, Government of India, New Delhi, India. 2008-2011.
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To study the role of notch signaling pathway in the pathogenesis of virus related hepatocellular carcinoma. Funded by Department of Biotechnology, Government of India, New Delhi, India. 2010-2013.
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