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Speciality

Research

Dr. Sukriti  
Dr. Sukriti
Assistant Professor (Molecular & Cellular Medicine)
 
Experience

Dr. Sukriti is PhD in Medicine from University of Delhi, with specialization in Hepato-immunology, Inflammation, Viral Immunology, Extracellular Vesicles and nanomedicine. She did three years of postdoctoral training at one of the world’s leading University, University of Illinois at Chicago (UIC), USA. Recipient of highly meritorious American Heart Association (AHA) postdoctoral award. She is also trained at Center for Research on Inflammation (INSERM), Paris, France for a year. Presently, she is working on extracellular vesicles (EVs), specifically microvesicles (MVs), as intercellular communicosomes and replacing cell therapies with EVs therapy as a potential revolutionary therapeutic tool which will be a new era in the field of regenerative medicine. Recently, she has published in Alimentary pharmacology and therapeutics that hepatic MVs are the baseline biomarkers to predict the response to corticosteroid therapy in severe alcoholic patients. She also published in Journal of viral hepatitis that EVs serve as reservoirs of HBV infection, carry HBV DNA after its clearance from plasma post treatment, mediate viral replication and can transmit infection. This novel data may help develop new therapeutic strategies or prophylactic options for the management of advanced liver diseases

Qualification

PhD Medicine (G.B Pant Hospital, Delhi University, Delhi)

Number of publications
32
Awards
  • Awarded with Young investigator award at European association for study of liver meeting 2020.
  • Awarded with Young investigator full bursary award at European association for study of liver meeting at Amsterdam, Netherlands, 2017.
  • Awarded with Young investigator full bursary award at European association for study of liver meeting at Barcelona, Spain, 2016.
  • Awarded best plenary oral presentation at Indian Society of Gastroenterology, Indore 2015.
  • Michael J. Bristow Postdoctoral Award for first best poster, September 2012.
  • Invited Oral Presentation at American Thoracic Society 2012.
  • Awarded with American heart association postdoctoral research fellowship 2012.
  • Full Bursary Young Investigator award at 45th European association for study of liver meeting at Vienna, Austria 2010.
  • Awarded with First Best Oral Presentation and Annual conference of Indian Society of Gastroenterology 2009 at Kolkata, India.
  • Abstract selected in TOP 10% at Annual meeting of European association for study of liver meeting at Copenhagen, Denmark, 2009.
  • APASL-AASLD Award of $ 1500 in 2008 at the 18th APASL conference 2008, Seoul, Korea.
  • Awarded with senior research fellowship from Lady Tata Memorial Trust, Mumbai, for the year 2007-2008.
  • Awarded with Young investigator full bursary award at 42nd European association for study of liver meeting at Spain, 2007.
  • Travel award by Liver foundation to give oral presentation at APASL conference at Japan, 2007.
  • Won first award for first best poster presentation at 47th Annual meeting of Indian society of Gastroenterology, Mumbai, 2006.
  • Second rank in quiz contest organized by Zoological Association, Kurukshetra University, Kurukshetra in the year 2004.
  • Second Rank at inter zonal level quiz competition organized by Zoological Association, Kurukshetra University in the year 2003.
  • Second Rank at state level essay Writing Competition organized by Haryana state council for science and technology in the year 2002.
  • Human Genome Project was adjudged first best working model at the state level working model competition organized by Govt. P.G College, Gurgaon for the year 2002 and the second best working model at the Inter Zonal Level competition hosted by Kurukshetra University Kurukshetra for the year 2002.
  • Awarded role of honour in 2002 by Govt. P.G College, Karnal.
  • Embryo Transfer Technology and Environmental Crisis Project were adjudged 1st at college level working model competition organized by Govt. P.G College, Karnal in the year 2001. Also honored with the Best Explanator award for the same.
  • First Award at inter zonal level working model competition organized by G.V.M Girls College, Sonipat in the year 1999.
Publications
  1. Joshi JC, Joshi B, Rochford I, Rayees S, Akhter MZ, Baweja S, Chava KR, Tauseef M, Abdelkarim H, Natarajan V, Gaponenko V, Mehta D. SPHK2-Generated S1P in CD11b + Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages. Cell Rep. 2020 Mar 24; 30(12):4096-4109.e5. doi: 10.1016/j.celrep.2020.02.112.
  2. Swati Thangriyal, Aayushi Rastogi, Arvind Tomar, Sukriti Baweja (corresponding author). Impact of Temperature and Sunshine Duration on Daily New Cases and Death due to COVID-19. MedRxiv preprint doi: https://doi.org/10.1101/2020.06.13.20130138
  3. Bihari C, Patil A, Shasthry SM, Baweja S, Kumar G, Sarin SK. Viscoelastic Test-Based Bleeding Risk Score Reliably Predicts Coagulopathic Bleeding in Decompensated Cirrhosis and ACLF Patients. Hepatol Int. 2020 Apr 17. doi: 10.1007/s12072-020-10036-y.
  4. Sukriti S, Choudhary MC, Maras JS, Sharma S, Thangariyal S, Singh A, Das S, Islam M, Sharma S, Trehanpati N, Gupta E, Sarin SK. Extracellular Vesicles From Hepatitis B Patients Serve As Reservoir Of Hepatitis B Virus DNA J Viral Hepat. 2019. Jan. doi: 10.1111/jvh.12995.
  5. Maras JS, Das S, Bhat A, Kumar Vyas A, Yadav G, Chaudhary S, Sukriti S, Gupta AC, Bihari C, Mahiwall R, Sarin SK. Dysregulated Lipid Transport Proteins Correlate With Pathogenesis and Outcome in Severe Alcoholic Hepatitis Hepatol Commun. 2019 Oct 30;3(12):1598-1625. doi: 10.1002/hep4.1438.
  6. Kaur S, Rawal P, Siddiqui H, Rohilla S, Sharma S, Tripathi DM, Baweja S, Hassan M, Vlaic S, Guthke R, Thomas M, Dayoub R, Bihari C, Sarin SK, Weiss TS. Increased Expression of RUNX1 in Liver Correlates With NASH Activity Score in Patients With Non-Alcoholic Steatohepatitis (NASH).  Cells. 2019 Oct 18;8(10):1277. doi: 10.3390/cells8101277.
  7. Sukriti S, Maras JS, Bihari C, Das S, Vyas AK, Sharma S, Hussain S, Shasthry S, Choudhary A, Premkumar M, Kumar D, Kumar G, Mukhopadhyay C, Kumar A, Trehanpati N, Rautou PE, Moreau R, Sarin SK. Microvesicles in hepatic and peripheral vein can predict nonresponse to corticosteroid therapy in severe alcoholic hepatitis. Aliment Pharmacol Ther. 2018 Feb 20.
  8. Bihari C, Lal D, Thakur M, Sukriti S, Mathur D, Patil AG, Anand L, Kumar G, Sharma S, Thapar S, Rajbongshi A, Rastogi A, Kumar A, Sarin SK.Suboptimal Level of Bone-Forming Cells in Advanced Cirrhosis are Associated with Hepatic Osteodystrophy. Hepatol Commun. 2018 Sep 4;2(9):1095-1110.
  9. Rayees S, Joshi JC, Tauseef M, Anwar M, Baweja S, Rochford I, Joshi B, Hollenberg MD, Reddy SP, Mehta D. PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+ Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation. Cell Rep. 2019 Apr 16;27(3):793-805.e4.
  10. Premkumar M, Saxena P, Rangegowda D, Baweja S, Mirza R, Jain P, Bhatia P, Kumar G, Bihari C, Kalal C, Vyas T, Choudhury A, Sarin SK. Coagulation failure is associated with bleeding events and clinical outcome during systemic inflammatory response and sepsis in acute-on-chronic liver failure: An observational cohort study. Liver Int. 2019 Apr;39(4):694-704. doi: 10.1111/liv.14034. Epub 2019 Feb 7.
  11. Premkumar M, Bihari C, Saxena P, Devurgowda D, Vyas T, Mirza R, Jain P, Kumar G, Bhatia P, Baweja S, Choudhury A, Sarin SK. Heparin-like Effect Associated With Risk of Bleeding, Sepsis, and Death in Patients With Severe Alcohol-Associated Hepatitis. Clin Gastroenterol Hepatol. 2019 May 8
  12. Pushpa Hegde, Emmanuel Weiss, Valérie Paradis, Jinghong Wan, Morgane Mabire, Sukriti Baweja, Pierre-Emmanuel Rautou, Miguel Albuquerque, Olivia Picq, Abhishek Gupta, Gladys Ferrerre, Hélène Gilgenkrantz, Badr Kiaf, Amine Toubal, Lucie Beaudoin, Philippe Leterron, Richard Moreau, Agnes Lehuen and Sophie Lotersztajn. Mucosal-Associated invariant T cells, a pro-fibrogenic immune cell population in the liver. Nature Communications, 2018.
  13. Maras JS, Das S, Sharma S, Sukriti S, Kumar J, Vyas AK, Kumar D, Bhat A, Yadav G, Choudhary MC, Sharma S, Kumar G, Bihari C, Trehanpati N, Maiwall R, Sarin SK.Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis. Sci Rep. 2018 Jul 6;8(1):10264.
  14. Das S, Maras JS, Maiwall R, Shasthry SM, Hussain S, Sharma S, Sukriti S, Singh TP, Sarin SK. Molecular Ellipticity of Circulating Albumin-Bilirubin Complex Associates With Mortality in Patients With Severe Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 2017 Nov 16.
  15. Sukriti Sukriti, Nirupma Trehanpati, Manoj Kumar, Chandana Pande, Syed S Hissar and Shiv Kumar Sarin. Functionally Aberrant Dendritic Cell Subsets and Expression of DC-SIGN Differentiate Acute from Chronic HBV Infection. Hepatol Int. 2016 Nov;10(6):916-923.
  16. Das S, Maras JS, Hussain S, Sharma S, David P, Sukriti S, Maiwall R, Trehanpati N, Singh TP, Sarin SK. Hyperoxidized Albumin Modulates Neutrophils to Induce Oxidative Stress and Inflammation in Severe Alcoholic Hepatitis. Hepatology. 2016 Oct 24. doi: 10.1002/hep.28897.
  17. Bihari C, Anand L, Rooge S, Kumar D, Saxena P, Shubham S, Sukriti, Trehanpati N, Kumar G, Pamecha V, Sharma S, Rastogi A, Kumar A, Sarin SK. Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver. Hepatology. 2016 Oct;64(4):1273-88.
  18. Tauseef M, Farazuddin M, Sukriti S, Rajput C, Meyer JO, Ramasamy SK, Mehta D. Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability. FASEB J. 2016 Jan;30(1):102-10.
  19. A Chavez, Tracy T, P Yazbeck, C Rajput, B Desai, S Sukriti, K Adams, N Knezevic, AB Malik and D Mehta. Cell Surface Internalization of Sphingosine-1-Phosphate (SIP) Receptor 1 Induced by Phosphorylation at Tyr143 Downregulates Receptor Signaling and Endothelial Barrier Enhancement Function of SIP. J Cell Sci. 2015 Jan 14. pii: jcs.154476
  20. Sukriti S, M Tauseef, P Yazbeck, and D Mehta. Mechanisms Regulating Endothelial Permeability. Pulmonary circulation, Sep.2014.
  21. Gupta AC, Trehanpati N, Sukriti S, Hissar S, Midha V, Sood A, Sarin SK. Interleukin-28b CC genotype predicts early treatment response and CT/TT genotypes predicts non-response in patients infected with HCV genotype 3. J Med Virol. 2014 Apr;86(4):707-
  22. Bose S, Tripathi DM, Sukriti, Sakhuja P, Kazim SN, Sarin SK. Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: association with hepatitis B related advanced liver disease and cancer. Gene. 2013 May 1;519(2):231-7.
  23. Tauseef M, Knezevic N, Chava KR, Smith M, Sukriti S, Gianaris N, Obukhov AG, Vogel SM, Schraufnagel DE, Dietrich A, Birnbaumer L, Malik AB, Mehta D. TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation. J Exp Med. 2012 Oct 22;209(11):1953-68.
  24. Trehanpati N, Shrivastav S, Shivakumar B, Khosla R, Bhardwaj S, Chaturvedi J, Sukriti, Kumar B, Bose S, Mani Tripathi D, Das T, Sakhuja P, Rastogi A, Bhihari C, Singh S, Gupta S, Kottilil S, Sarin SK. Analysis of Notch and TGF-β Signaling Expression in Different Stages of Disease Progression During Hepatitis B Virus Infection. Clin Transl Gastroenterol. 2012 Oct 4;3:e23.
  25. Nirupma Trehan Pati, Sukriti, Robert Geffers, Syed Hissar, Peggy Riese, Tanja Toepfer, Carlos A. Guzman and Shiv Kumar Sarin. Acute and Resolving Phase of HEV Infected Patients and Its Cellular Immune and global gene expression patterns. Journal of Clinical Immunolology, 2011 Feb 3. 2011 Jun;31(3):498-508.
  26. Nirupma Trehan Pati, Shyam Kotillil, Syed S Hissar, Shikha Shrivastava, Arshi Khanam, Sukriti Sukriti, Siddartha K Mishra and Shiv Kumar Sarin. Circulating Tregs correlate with viral load reduction in chronic HBV-treated patients with tenofovir disoproxil fumarate. Journal of Clinical Immunolology, 2011 Jun; 31(3):509-20.
  27. Sukriti, Nirupma Trehan pati, Sujoy Bose, Syed S Hissar. Impaired antigen processing and presentation machinery is associated with immunotolerant state in chronic hepatitis B virus infection. Journal of Clinical immunology, 2010 May; 30(3):419-25.
  28. AC Gupta, AK Choudhary, Sukriti, C Pande, P Sakhuja, Y Singh, SF Basir, S.K.Sarin. Peroxisome Proliferators Activated Receptor γ2 Pro12Ala Variant Is Associated with Body Mass Index (BMI) in Nonalcoholic Fatty liver disease Patients. Hepatol Int. 2010 Dec 1;5(1):575-80.
  29. Nirupma TrehanPati, Robert Geffers(equal contributors), Sukriti, Syed Hissar, Peggy Riese, Tanja Toepfer, Jan Buer, Manoj Kumar, Carlos A. Guzman and Shiv Kumar Sarin .Gene Expression Signatures of Peripheral CD4+T Cells Clearly Discriminate Between Patients with Acute and Chronic Hepatitis B Infection. Hepatology. 2009; March 49:781-790.
  30. K. Manohar, P V Suneetha, Sukriti,  Nirupama Trehan Pati, Abhishek C Gupta, Syed Hissar, Puja Sakhuja, S K Sarin. Association of IL-18 promoter polymorphism with liver disease severity in HCV infected patients. Hepatology International 2009 Jun;3(2):371-7.
  31. Sukriti, Nirupma Trehan Pati, Ankur Sethi, Kireet Agrawal,  Kamal Agrawal, Gollapudi Tharun Kumar, Manoj Kumar, Anjur Tupil Kaanan and Shiv Kumar Sarin. Low levels of awareness, vaccine coverage, and the need for boosters among health care workers in tertiary care hospitals in India. Journal of Gastroenterology and Hepatology. 2008 Nov;23(11):1710-5.
  32. Nirupma TrehanPati, Sukriti, Syed Hissar, Kamal Agrawal, Rajni Rani, Shiv Kumar Sarin.Decrease In CD4+ T Lymphocyte Proliferation Responses And Enhanced CD150 Cell Expression In Health Care Workers Non-Responsive To HBV Vaccine. Vaccine. 2007 Feb 26;25(10)1848-1855.

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