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Speciality

Research

Dr. Savneet Kaur  
Dr. Savneet Kaur
Associate Professor
 
Experience

18 years post PhD (2006)

Qualification

PhD Biochemistry Institute of Genomics and Integrative Biology - 2006

MSc Kurukshetra University 2001

Awards
  • Goyal Award, M.Sc toppers, Kurukshetra University, 2001.
  • Junior and Senior Research Fellowship, Council for Scientific and Industrial Research, India, Jan 2002-Dec 2005.
  • Postdoctoral fellowship, Department of Biotechnology, India, July 2006-June 2009.
  • International Travel Award, Indian National Science Academy and Department of Science and Technology, to attend the 35th Annual Scandinavian Society for Immunology, June 2004, Aarhus, Denmark.
  • International Travel Fellowship, Poster presentation at the 18th FAOBMB symposium, Nov 2005, Lahore, Pakistan.
  • Best poster award, 7th Indo-US workshop organized by Indo-US forum at Trivandrum, Kerala, India, Feb 2007 in Kerala, India.
  • International Travel Award by Department of Science and Technology, India for poster presentation at the 2008 Meeting of International Society for Heart Research, Cell to Bedside, June 2008, Cincinnati, Ohio.
  • Young Investigator Travel, Award by American Association for the Study of Liver Diseases for presentation at AASLD conference, Oct 2010, Boston, USA.
  • DST Travel Award, to present at the 64th Annual Meeting of the American Association for the Study of Liver Diseases at Washington, DC, from 1st Nov - 5th Nov, 2013.
  • Best poster award, 16th Indo-US Flow Cytometry Workshop held at ILBS, New Delhi from 27th-28th Oct, 2014.
  • ICMR Travel Award, to present at the 67th Annual Meeting of the American Association for the Study of Liver Diseases at Boston, MA, from 11th Nov - 15th Nov, 2016.
  • Second Best Poster Award, DSUMP 2017 held at School of Biotechnology, Gautam Buddha University, from 10th-11th Jan, 2017.
  • SERB Travel Award, to present at ‘The Liver Sinusoid Meeting’, Sydney, 4th to 7th Sept, 2019.
  • SERB International Research Experience (SIRE) Fellowship to visit ‘Regenerative and Bioengg. Lab’ in Zaragoza, Spain, 17June to 12 Aug, 2022.

Membership

  • Nominated member of the CPCSEA, Govt of India
  • Life member, Association of Clinical Biochemists of India (ACBI)
  • Council Member, International Society for Hepatic Sinusoid Research (ISHSR)
  • Member, European Association for the Study of Liver (EASL)
  • Editorial board member, Journal of Clinical and Translational Hepatology, BMC Gastroenterology, Frontiers Physiology, Biodesign and Manufacturing Journal
Research Int

Liver Angiogenesis and Lymphangiogenesis in Liver Disease and Regeneration, Lymphatic System Biology, Liver Tissue Engineering

Research Work

My lab in ILBS is focused to investigate underlying mechanisms of liver regeneration and pathophysiology (fibrosis, cirrhosis and cancer) and explore novel therapeutic options for end-stage liver diseases. I have a specialization and interest in studying liver vascular biology, endothelial cells, Faculty angiogenesis and lymphangiogenesis. I first reported paracrine interactions of BM-derived circulating endothelial progenitor cells (EPCs) with liver sinusoidal endothelial cells (LSECs) in promoting intrahepatic angiogenesis and fibrosis in liver cirrhosis. We documented novel role of endothelial cell-specific Runt-related transcription factor (RUNX1) in regulating angiogenesis in non-alcoholic fatty liver disease. Recently, we reported the protective role of gut lymphangiogenesis in cirrhosis. We are currently investigating the role of bile acids in angiogenesis and liver regeneration. We are

Expertise Area

Liver Vascular Biology

Trainings
  • European Society for the Study of the liver (EASL), Barcelona, Spain, 18th-22nd April, 2012.
  • Indo-German Workshop on Regenerative Diseases, 14th to 16th February 2013, Institute of liver and biliary Sciences, New Delhi.
  • 24th mid-year meeting of Indian Academy of Sciences, 4th-6th July, 2013, IISC, Bangalore.
  • 64th Annual Meeting of the American Association for the Study of Liver Diseases at Washington, DC, from 1st Nov - 5th Nov, 2013.
  • 16th Indo-US Flow Cytometry Workshop held at ILBS, New Delhi from 27th-28th Oct, 2014.
  • Indo French Node on Liver Diseases, Meeting, 16th-18th Jan, 2015, Institute of liver and biliary Sciences, New Delhi.
  • Research Retreat, 19th-20th June, 2015, University of Regensburg, Regensburg, Germany.
  • 42nd Annual Conference of Association of Clinical Biochemists of India (ACBICON 2015), 25th to 28th Nov, 2015, Chandigarh, India.
  • 67th Annual Meeting of the American Association for the Study of Liver Diseases at Boston, MA from 11th Nov - 15th Nov, 2016.
  • National Conference on Biotechnology and Environment, Organized by Jamia, Millia Islamia University, New Delhi on 10th-11th April, 2017.
  • Asia Pacific Association for study of liver disease (APASL, 2018), New Delhi, 14th-18th March, 2018.
  • Indo-French Meeting, 19th Mar, 2018, Institute of liver and biliary Sciences, New Delhi.
  • Indo-French Conference, 19th-20th Jan, 2019, Institute of liver and biliary Sciences, New Delhi.
  • European Association for study of liver (EASL 2019), Vienna, 10th-14th April, 2019.
  • The Liver Sinusoid Meeting, Sydney, 4th to 7th Sept, 2019
  • BioTERM, Therapeutic Engineering and Regenerative Medicine, 28th Nov-1st Dec, 2019, IIT Kanpur, UP.
  • American Association for the Study of Liver Diseases at Boston, MA from 8th Nov - 12th Nov, 2019 and Hot Topics in AASLD at Hyderabad, 4th and 5th Jan, 2020.
  • Korea Digestive Week (KDDW) entitled: ‘Biliary Organoids Engraft and Differentiate into Functional Hepatocytes in Chronically-injured Mice Liver’. 18-20th Nov, 2021.
  • Invited Talk, 47th National Conference of Association of Clinical Biochemists of India, 12-15th Dec, 2021.
  • Invited lectures on Liver Biology and Tissue Engg., National University of Singapore, March, 2022.
  • Invited Talk on ‘In vitro Modeling of Liver Sinusoid’, International Society for Hepatic Sinusoidal Research (ISHSR) Meeting, 2nd and 3rd Sept, 2022.
  • Invited Talk on ‘Liver Organoids’, Biodesin, Biomaterials and Manufacturing Conference at Singapore, 6th-8th Aug, 2023.
  • Invited Talk on ‘Lymphatic Vessels in Cirrhosis’, 7th International Conference on Translation Research, AIIMS, 16th – 18th Oct, 2023.
  • Invited Talk on ‘Unlocking the Potential of Liver Organoids’, International Conference on Biomaterials and Healthcare Technologies’ 29th Nov-1st Dec, 2023.
  • Invited Lecture on ‘Lymphatics in Liver Cirrhosis: A New Target for Therapy’, Brainstorming & Updates on Innovations in Liver Diseases, 19th -21st Jan, 2024.
Publications

In Refereed Journals: 60

Book Chapters: 05

Patents: 04

 

  • Savneet Kaur and Barkha Singhal. When nano meets stem: the impact of nanotechnology in stem cell biology. J Biosci Bioeng., 2012;113:1-4
  • Savneet Kaur, Ketki V. Dongre, Dinesh M. Tripath, Vishal Garg, Sheetalnath Rooge, Puja Sakhuja, Asok Mukopadhyay, Shiv K. Sarin. Increased numbers and functions of circulating endothelial progenitor cells enhance angiogenesis in chronic liver diseases through paracrine factors. J. Hepatol., 2012;57:1193-8.
  • Savneet Kaur and Shweta Singh. Biofilm formation by Aspergillus fumigatus. Med. Myc., 2014;52:2-9.
  • Savneet Kaur and Preety Bajwa. A tete-e-tete between cancer stem cells and endothelial progenitor cells in tumor angiogenesis. Clin. Trans. Oncol., 2014;16:115-21.
  • Savneet Kaur and K. Anita. Angiogenesis in liver regeneration and fibrosis: A double-edged sword. Hep Int., 2014:7:959-968.
  • Deepti Vyas, Skand Gupt, Vaibhav Dixit, Anita K and Savneet Kaur. To study the effect of curcumin on the growth properties of circulating endothelial progenitor cells. In Vitro Cell Dev Biol Anim., 2015:51:488-494.
  • Savneet Kaur, H Siddiqui, MH Bhat. Hepatic Progenitor Cells in Action: Liver Regeneration or Fibrosis? Am J Pathol. 2015 Sep;185(9):2342-50.
  • M Singh, L Mahajan, N Chaudhary N, Savneet Kaur, T Madan and PU Sarma. Murine models of Aspergillosis: Role of collectins in host defense. Indian J Exp Biol. 2015;53:691-700.
  • Manali Garg, Savneet Kaur, Arpita Banik, Vikash Kumar, Shiv K. Sarin, Asok Mukhopadhyay, Nirupma Trehanpati. Bone Marrow Endothelial Progenitor Cells Activate Hepatic Stellate Cells And Aggravate Carbon Tetrachloride Induced Liver Fibrosis in Mice via Paracrine Factors. Cell Proliferation. 2017;50.
  • Upasana Rishiraj, Sumati Rohilla, Savneet Kaur. Correlation between intron 4 polymorphism of the endothelial nitric oxide synthase gene and cardiovascular risk with the numbers of circulating endothelial progenitor cells in healthy subjects. Indian J Biochem., 2017; 1-6.
  • Nigam N, Bihari C, Lal D, Rastogi A, Kumar S, Pamecha V, Savneet Kaur, Kumar A,Sarin SK. Donor CD163 and nestin-positive cells predict graft function in living donor liver transplant. Clin Transplant. 2018;32:e13197.
  • Savneet Kaur, Sehgal R, Shastry SM, G McCaughan, HM McGuire, BM Fazekas St de Groth, S Sarin, N Trehanpati, D Seth. Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients With Alcoholic Liver Cirrhosis. Front Physiol 2018; 9:556. doi: 10.3389/fphys.2018.00556.
  • Kaur I, Rawal P, Rohilla S, Bhat MH, Sharma P, Siddiqui H, Savneet Kaur. Endothelial progenitor cells from aged subjects display decreased expression of Sirtuin 1, angiogenic functions and increased senescence. Cell Biol Int. 2018; doi: 10.1002/cbin.10999.
  • Hamda Siddiqui, Preety Rawal and Savneet Kaur. Paracrine Interactions of Hepatoma Cells with Endothelial Cell and Fibroblastic Cells. Int. J. Pure App. Biosci. 2018; 6: 1695-1699.
  • Rawal P, Siddiqui H, Bhat MH, Choudhary MC, Tripathi DM, Nain V, Trehanapati N, Savneet Kaur. Endothelial cell-derived TGF-β Promotes Epithelial-Mesenchymal Transition via CD133 in HBx-infected Hepatoma cells. Front Oncol. 2019;9:308. doi: 10.3389/fonc.2019.00308.
  • Savneet Kaur, Preety Rawal, Hamda Siddiqui, Sumati Rohilla, Shvetank Sharma, Dinesh M Tripathi, Sukriti Baweja, Mohsin Hassan, Sebastian Vlaic, Reinhard Guthke, Maria Thomas, Rania Dayoub, Chaggan Bihari, Shiv K Sarin and Thomas S. Weiss. Increased expression of RUNX1 in Liver Correlates with NASH Activity Score in Patients with Non-Alcoholic Steatohepatitis (NASH). Cells, 2019; 8. doi: 10.3390/cells8101277.
  • Rashi Sehgal, Savneet Kaur, Saggere Murli Shasthry, Tanvi Agrawal, Varsha Dwivedi, Devanshi Seth, Gayatri Ramakrishna, Shiv Kumar Sarin and Nirupma Trehanpati. Natural Killer Cells Contribute to Pathogenesis of Severe Alcoholic Hepatitis by Inducing Lysis of Endothelial Progenitor Cells. Alcoholism: clinical and experimental research. 2019; doi: 10.1111/acer.14242.
  • Hamda Siddiqui, Preety Rawal, Naveen Arora, Chaggan Bihari, Savneet Kaur.Vascular endothelial growth factor promotes proliferation of EpCAM-positive cells in non-alcoholic alcoholic steatohepatitis. Journal of Clinical and Experimental Hepatology. 2019; doi: 10.1016/j.jceh.2019.11.011.
  • Savneet Kaur, Dinesh M.Tripathi, Jayarama Reddy Venugopal, Seeram Ramakrishna. Advances in biomaterials for hepatic tissue engineering. Current Opinion in Biomedical Engineering. 2020; 13, 190-196.
  • Dinesh Mani Tripathi, Mohsin Hassan, Hamda Sidiqqui, Impreet Kaur, Preety Rawal, Chaggan Bihari, Savneet Kaur and Shiv K Sarin. Cirrhotic Endothelial Progenitor Cells Enhance Liver Angiogenesis and Fibrosis and Aggravate Portal Hypertension in Bile Duct-Ligated Cirrhotic Rats. Front Physiol. 2020. 11: 617.
  • Savneet Kaur, Dinesh M Tripathi, Angeera Yadav. The Enigma of Endothelium in COVID-19. Front Physiol. 2020; 11: 989.
  • Savneet Kaur, Dinesh M Triparthi, Sourabh Ghosh. Three-dimensional bioprinted hepatorganoids in liver failure. GUT. 2020; 322317.
  • Kailash Kolhe, Dinesh M Triparthi, Savneet Kaur Management of Portopulmonary hypertension: What is more important: PAH severity or liver disease severity? J Hepatology, 2020; 20:30473-6.
  • Sumati Rohilla, Ankita Awasthi, Savneet Kaur, Rekha Puria. Evolutionary conservation of long non-coding RNAs in Non-Alcoholic Fatty Liver Disease. Life Sciences. 2020;118560
  • Kaur S, Hussain S, Kolhe K, Kumar G, Tripathi DM, Tomar A, Kale P, Narayanan A, Bihari C, Bajpai M, Maiwall R. Elevated plasma ICAM1 levels predict 28-day mortality in cirrhotic patients with COVID-19 or bacterial sepsis. JHEP Rep. 2021:100303.
  • Tripathi DM, Rohilla S, Kaur I, Siddiqui H, Rawal P, Juneja P, Kumar V, Kumari A, Naidu VGM, Ramakrishna S, Banerjee S, Puria R, Sarin SK, Kaur S. Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH. Int J Mol Sci. 2021;22(16):8489. IF: 5.92.
  • Sharma A, Rawal P, Tripathi DM, Alodiya D, Sarin SK, Kaur S, Ghosh S. Upgrading Hepatic Differentiation and Functions on 3D Printed Silk-Decellularized Liver Hybrid Scaffolds. ACS Biomater Sci Eng. 2021;7(8):3861-3873. IF: 4.74.
  • Juneja P, Tripathi DM, Kaur S. Revisiting the gut-liver axis: gut lymphatic system in liver cirrhosis and portal hypertension. Am J Physiol Gastrointest Liver Physiol. 2022 Feb 23. doi: 10.1152/ajpgi.00271.2021. IF: 4.05.
  • Rawal P , Tripathi DM, Nain V, Kaur S. VEGF-mediated tumour growth and EMT in 2D and 3D cell culture models of hepatocellular carcinoma. Oncology Letters. 2022; 24: 315.
  • Biswas S, Vasudevan A, Yadav N, Yadav S, Rawal P, Kaur, I; Tripathi DM, Kaur S*, Chauhan V. A chemically modified dipeptide based hydrogel supports three-dimensional growth and functions of primary hepatocytes. ACS Applied Bio Materials. 2022.
  • Vasudevan, Ashwini, Dinesh M. Tripathi, Subramanian Sundarrajan, Jayarama Reddy Venugopal, Seeram Ramakrishna, and Savneet Kaur. 2022. "Evolution of Electrospinning in Liver Tissue Engineering" Biomimetics 7, no. 4: 149.
  • Biswas S, Yadav N, Juneja P, Mourya AK, Kaur S, Tripathi DM, Chauhan VS. Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis. ACS Omega. 2022;7:36811-36824.
  • Kaur S, Kidambi S, Ortega-Ribera M, Thanh Thuy LT, Nieto N, Cogger VC, Xie W-F, Tacke F, Gracia-Sancho J, In vitro models for the study of liver biology and diseases – advances and limitations, Cellular and Molecular Gastroenterology and Hepatology. (2022), doi: https:// doi.org/10.1016/j.jcmgh.2022.11.008.
  • Kaur I, Vasudevan A, Rawal P, Tripathi DM, Ramakrishna S, Kaur S, Sarin SK. Primary Hepatocyte Isolation and Cultures: Technical Aspects, Challenges and Advancements. Bioengineering (Basel). 2023 Jan 18;10(2):131.
  • Simran Sharma, Preety Rawal, Savneet Kaur, Rekha Puria. Liver organoids as a primary human model to study HBV-mediated Hepatocellular carcinoma. Experimental Cell Research. Volume 428, Issue 1, 2023.
  • Juneja P, Sharma A, Shasthry SM, Kumar G, Tripathi DM., Rajan V, Rastogi A, Sarin SK, Kaur S*. Podoplanin-positive dilated lymphatic vessels in duodenum associates with three-month mortality in patients with cirrhosis. Frontiers in Physiology. 2023. Volume 14. doi:10.3389/fphys.2023.1045983. IF: 4.755.
  • Pinky Juneja, Syed Nazrin Ruhina Rahman, Deepika Jakhar, Akash Kumar Mourya, Dinesh M. Tripathi, Impreet Kaur, Vaibhav Tiwari, Sumati Rohilla, Abhishek Gupta, Preety Rawal, Sukriti Baweja, Archana Rastogi, V.G.M. Naidu, Shiv K. Sarin, Subham Banerjee, Savneet Kaur. Recombinant VEGF-C (Cys156Ser) improves mesenteric lymphatic drainage and gut immune surveillance in experimental cirrhosis, JHEP Reports, 2023, doi.org/10.1016/j.jhepr.2023.100816.
  • Rawal P, Tripathi DM, Hemati H, Kumar J, Tyagi P, Sarin SK, Nain V, Kaur S. Targeted HBx gene editing by CRISPR/Cas9 system effectively reduces epithelial to mesenchymal transition and HBV replication in hepatoma cells. Liver Int. 2024;44(2):614-624.
  • Savneet Kaur and CC Kartha. Stem Cells: Concepts and Prospects. Current trends in Science. Platinum Jubilee Special, Indian Academy of Sciences. 2009: 438-452.
  • Savneet Kaur, Kavita Kale, Taruna Madan. Mechanisms of Pathogenesis of Aspergillosis. In Microbial Pathogenesis: Infection and Immunity. Ed. Uday Kishore and Annapurna Nayak. Springer. 2014.
  • Savneet Kaur and Upasana Rishiraj. 2015. Nanotechnology and Cardiovascular Tissue Engineering. In Hossein Baharvand ed. Stem Cell Nanoengineering. Wiley-Blackwell. Pg. 285.
  • Savneet Kaur, Impreet Kaur, and CC Kartha. The Emerging role of Cardiac Stem Cells in Cardiac Regeneration. In Tarun Pandey Ed. Imaging in Stem Cell Transplant and Cell-based therapy. Springer. 2017. Pg. 101.
  • Savneet Kaur. Cardio-toxic effects of Tyrosine kinase inhibitors directed against VEGFR. In Qamar and Maurya Ed. Cardiovascular toxicity and therapeutic modalities targeting cardio-oncology. Elsevier. 2022.

 

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