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Speciality

Research

Dr. Jaswinder Singh Maras  
Dr. Jaswinder Singh Maras
Associate Professor
 
Experience

2019-12 – Current Assistant Professor

  • Institute of Liver and Biliary Sciences , New Delhi
  • PhD supervisor for 4 students, Co-supervisor for 3 students and helped and cosupervised 4 DM student thesis
  • Group leader in Proteomics and Metabolomics at ILBS and published > 35 research articles in peer-reviewed journals including Hepatology premiere journals The Hepatology, J Hepatology, HepCOM, JHep Reports and others
  • Collaborated nationally with CDRI, NII, ICGEB, THSTI, JNU , and Internationally with the Kings Hospital, Institute of Hepatology, Imperial institute london , CEASACLAY France

2015-03 - 2020-03 DST-INSPIRE Faculty (Assistant Professor )

  • Department of Science and Technology and ILBS , New Delhi
  • Established the Proteomics and Metabolomics laboratory at the ILBS
  • Established and standardized technique like Meta-proteomics , Proteomics, Metabolomics and Lipidomics at the ILBS

2014-01 - 2015-01 Research Associate (Post Doctoral Fellow )

  • CEA-SACLAY (FRANCE) and ILBS -INDIA, GIf-sur yvette
  • Joint Postdoctoral Research Associate at Laboratoire d'Etude du Métabolisme des Médicaments, Institut de Biologie et de Technologie de Saclay, Saclay, and Institute of liver and biliary sciences New Delhi.
Qualification
(2008-oct – 2013-oct) Ph.D.: Medicine: Faculty of Medicine, University of Delhi - New Delhi
  To Study The Proteome Profile And Identification Of Potential Biomarkers For The Evaluation Of Patients With Acute And Acute On Chronic Liver Failure under the supervision of Dr. Shiv Sarin.
2005-03 – 2007 Master of Science: Biochemistry University Department of Biochemistry – Nagpur
2002-05 – 2005 Bachelor of Science: Biochemistry Sindhu Mahavidayala - Nagpur
Awards

Awards/ Membership (Till Date):

  • Awarded the Prestigious INSPIRE FACULTY AWARD from the Department of Science and Technologies Government of INDIA (2015-2020).
  • Invited to join the Editorial board for World journal of Hepatology ( 2014-2017) (International peer reviewed journal) Editorial Board ID: 02861049
  • Awarded best poster award in ILC 2011 EASL for the CD 163, A Candidate Circulating Biomarker For Evaluation Of Patients With Acute On Chronic Liver Failure And Can Predict Hepatic Encephalopathy
  • Selected for young investigator award (full bursary) for 6 continuous years from 2011-2015.
  • Invited for oral presentation at the International Liver Congress (ILC EASL-amsterdam- 2013) for A Proteomic Approach To Identify Dysregulated Lipid Transporter Proteins Which Could Predict The Severity And
  • Outcome Of Patients With Acute On Chronic Liver Failure
  • Selected as Best Poster award at the ALPD international symposium for A Proteomic Approach To Identify
  • Dysregulated Lipid Transporter Proteins Which Could Predict The Severity And Outcome Of Patients
  • With Acute On Chronic Liver Failure.
  • Invited for oral presentation for Pon1 Directed Recalibration Of Macrophage Lipid Homeostasis 
  • Leads To Reversal Of Circulating Foamy Phenotype And Predicts Outcome In Acute On Chronic Liver Failure (ACLF) at Hepatology 360 -2014
Clinical Int
  • Severe Alcoholic Hepatitis
  • ACLF
  • Sepsis
  • Iron overload
  • Biomarkers
Research Int

Research Work

  • Circulating bacterial peptides and linked metabolomic signatures are indicative of early mortality in Paediatric Cirrhosis
  • Comparative metabolome analysis reveals higher potential of hemoperfusion adsorption in providing favourable outcome in ACLF patients
  • Multi-omics analysis identifies potential microbial and metabolite diagnostic biomarkers of bacterial vaginosis
  • Biomolecular map of albumin identifies signatures of severity and early mortality in acute liver failure
  • Bile multi‐omics analysis classifies lipid species and microbial peptides predictive of carcinoma of gallbladder
  • Global metabolome profiling of COVID-19 respiratory specimen using high-resolution mass spectrometry (HRMS)
  • Protocol for global proteome, virome, and metaproteome profiling of respiratory specimen (VTM) in COVID-19 patient
  • Multi-omics analysis of respiratory specimen characterizes baseline molecular determinants associated with SARS-CoV-2 outcome
Expertise Area

Clinical Mass spectrometry - Proteomics and Metabolomics and lipidomice in Hepatology.
Project Awarded: Principal Investigator: (N=7)

  • 1) “A Proteomic and Metabolomics investigation to identify candidate biomarkers for Acute Liver Failure (ALF) and  Acute on Chronic Liver Failure (ACLF) using high resolution mass spectrometry” Budget - 35 lakhs, Duration- 5 years (2015-2020) , Awarded by Department of science and technology Govt. of INDIA
  • 2) A proteomic investigation to outline the mechanism associated for Non Response to corticosteroids in patients with severe alcoholic hepatitis" Budget – 60 lakhs ,Duration- 3years (2017-2019), Awarded by Department of science and technology Govt. of INDIA
  • 3) A proteomic investigation to identify and characterize differentially expressed albuminome to predict early mortality in Acute on Chronic Liver Failure (ACLF) and Acute Liver Failure (ALF) by using high resolution mass spectrometry Budget 90 lakhs, Duration- 3years (2021-2023), Awarded by ICMR Govt. of INDIA )
  • 4) A proteomic investigation to delineate the role of platelets and plasma proteins in liver regeneration in living donor liver transplantation.—ICMR 60 lakhs (2023-2026) 
  • 5) To understand the hepato-protective and hepatotoxic mechanism associated to Ayurvedic formulation validated in plasma samples of patients under treatment with Ayurvedic drugs” --- Ministry of AAYUSH --- 10 CR(2022-2025)
Trainings

More than 50 conference publications including EASL and AASLD conference

Publications
Srno. Publication[Citations >590 , H-index-15, i10-index-19] Journal of publication Year of publication Impact factor Author status
50 Circulating bacterial peptides and linked metabolomic signatures are indicative of early mortality in Paediatric Cirrhosis babu mathew, gaurav tripathi, vipul gautam Maras JS Hepatology communication 2024 Hepatology communication 2024 5.2 Corresponding Author
49 Multi‐omics analysis identifies potential microbial and metabolite diagnostic biomarkers of bacterial vaginosis A Challa, JS Maras, S Nagpal, G Tripathi, B Taneja, G Kachhawa, S Sood, ... Journal of the European Academy of Dermatology and Venereology Journal of the European Academy of Dermatology and Venereology 2024 10.4 Second Author
48 Modulation of CD8+ T cells, NK cells and Th1cytokines by metabolic milieu in decline of HBV-viremia in pregnant women treated with Tenofovir-disoproxil from second trimester of … P Pahwa, AK Vyas, JK Sevak, R Singh, JS Maras, S Patra, SK Sarin, ... Journal of Reproductive Immunology, 104208 Journal of Reproductive Immunology 2024 3.5 Co-Author
47 Comparative metabolome analysis reveals higher potential of hemoperfusion adsorption in providing favourable outcome in ACLF patients Liver international 2024 8.1 Corresponding Author
46 Metabolic alterations unravel the maternofetal immune responses with disease severity in pregnant women infected with SARS‐CoV‐2 Journal of Medical Virology 2023 12.7 Co-Author
45 Thiourea Derivatives Restore Dysfunctional Mitochondria in Chronic Hepatitis B Infection Journal of Proteomics & 2023 5.5 Co-Author
44 Multi-omics analysis identifies potential microbial and metabolite diagnostic biomarkers of bacterial vaginosis Bioinformatics Journal of the European Academy of Dermatology and Venereology 2023 10.5 Co-Author
43 Withaferin A Protects against Primary and Recurrent Tuberculosis by Modulating Mycobacterium-Specific Host Immune Responses A Kumari, I Pahuja, K Negi, A Ghoshal, S Mukopadhyay, M Agarwal, … Microbiology Spectrum 11 (2), e00583-23 Microbiology Spectrum 2023 8.8 Co-Author
42 SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis A Bhaskar, I Pahuja, K Negi, A Verma, A Ghoshal, B Mathew, G Tripathi, ... JS Maras Iscience 26 (5) 2023 5.8 Co-Author
41 Biomolecular map of albumin identifies signatures of severity and early mortality in acute liver failure N Sharma, S Pandey, M Yadav, B Mathew, V Bindal, N Sharma, G Tripathi, … Journal of Hepatology 79 (3), 677-691 Journal of Hepatology 2023 27 Corresponding Author
40 Ocimum sanctum Alters the Lipid Landscape of the Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in a Mouse Model I Yadav, N Sharma, R Velayudhan, Z Fatima, JS Maras Life 13 (9), 1877 2023 3.3 Corresponding Author
39 Early hepatic proteomic signatures reveal metabolic changes in high-fat-induced obesity in rats.
AC Gupta, A Bhat, JS Maras
British Journal of Nutrition, 1-13 2023 3.9 Co-Author
38 Berberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis. Isha Pahuja, Kriti Negi, Anjna Kumari, Meetu Agarwal, Suparba Mukhopadhyay, Babu Mathew, Shivam Chaturvedi, Jaswinder Singh Maras, Ashima Bhaskar, Ved Prakash Dwivedi.Plos pathogen accepted article Plos pathogen 2023 7.5 Co-Author
37 Metabolomic analysis shows dysregulation in amino acid and NAD+ metabolism in palmitate treated hepatocytes and plasma of non-alcoholic fatty liver disease spectrum. Savera Aggarwal , Vipin Yadav , Rakhi Maiwall , Archana Rastogi , Viniyendra Pamecha , Onkar Bedi , Jaswinder Singh Maras , Nirupma Trehanpati , Gayatri Ramakrishna Biochemical and Biophysical Research Communications 643, 129-138 Biochemical and Biophysical Research Communications 2023 3.3 Co-Author
36 Reply to - For the core set of the bile lipidome and meta‐proteome signature, repeatability is the key: Nupur Sharma , Manisha Yadav , Gaurav Tripathi , Babu Mathew , Vasundhra Bindal , Sanyam Falari , Viniyendra Pamecha , Jaswinder Singh Maras Hepatology 76 (4), E74-E75 Hepatology 2022 17.4 Corresponding Author
35 Bile multi‐omics analysis classifies lipid species and microbial peptides predictive of carcinoma of gallbladder. Nupur Sharma , Manisha Yadav , Gaurav Tripathi , Babu Mathew , Vasundhra Bindal , Sanyam Falari , Viniyendra Pamecha , Jaswinder Singh Maras ; Hepatology 76 (4), 920-935 Hepatology 2022 17.4 Corresponding Author
34 Downregulation of gamma subunit of TCP1 chaperonin of Leishmania donovani modulates extracellular vesicles-mediated macrophage microbicidal function; S Yadav, A Anand, DC Balodi, K Ramalingam, K Mitra, JS Maras, N Goyal ;Microbial Pathogenesis 169, 105616 Microbial Pathogenesis 2022 3.8 Co-Author
33 Plasma proteomic analysis identified Proteins Associated with Faulty Neutrophils functionality in decompensated cirrhosis patients with Sepsis; R Sehgal, N Kaur, R Maiwall, G Ramakrishna, JS Maras, N Trehanpati ;Cells 11 (11), 1745 Cells 2022 7.7 Corresponding Author
32 Unraveling of interacting protein network of chaperonin TCP1 gamma subunit of Leishmania donovani; S Yadav, A Anand, K Ramalingam, DC Balodi, JS Maras, N Goyal ;Cell Stress and Chaperones 27 (3), 205-222 Cell Stress and Chaperones 2022 3.7 Co-Author
31 Global metabolome profiling of COVID-19 respiratory specimen using high-resolution mass spectrometry (HRMS); N Sharma, SH Bhat, G Tripathi, M Yadav, B Mathew, V Bindal, S Sharma, ...JS Maras ;STAR protocols 3 (1), 101051 Cell Press STAR protocols 2022 TBA Corresponding Author
30 Protocol for global proteome, virome, and metaproteome profiling of respiratory specimen (VTM) in COVID-19 patient by LC-MS/MS-based analysis; G Tripathi, N Sharma, V Bindal, M Yadav, B Mathew, S Sharma, E Gupta, ...JS Maras; STAR protocols 3 (1), 101045 Cell press STAR protocols 2022 TBA Corresponding Author
29 Baseline Plasma Metabotype Correlates With Direct-Acting Antiviral Therapy Nonresponse for HCV in HIV–HCV Coinfected Patients. G Tripathi, S Rooge, M Yadav, B Mathew, N Sharma, V Bindal, H Hemati, ... JS Maras; Frontiers in Molecular Biosciences 8, 1342 Frontiers in Molecular Biosciences 2022 6.5 Corresponding Author
28 Sustained expression of inflammatory monocytes and activated T cells in COVID‐19 patients and recovered convalescent plasma donors. R Singh, H Hemati, M Bajpai, P Yadav, A Maheshwari, S Kumar, … JS Maras, Immunity, inflammation and disease 9 (4), 1279-1290 Immunity, inflammation and Disease 2021 2.5 Co-Author
27 Albumin in advanced liver diseases: the good and bad of a drug!; RK Jagdish, JS Maras, SK Sarin. Hepatology 74 (5), 2848-2862 Hepatology 2021 17.5 Co-Second Author
26 Multi-omics analysis of respiratory specimen characterizes baseline molecular determinants associated with SARS-CoV-2 outcome. JS Maras, S Sharma, A Bhat, S Rooge, E Gupta, SK Sarin. Iscience 24 (8), 102823 Iscience 2021 6.5 First and Corresponding Author
25 Circulating extracellular vesicles induce monocyte dysfunction and are associated with sepsis and high mortality in cirrhosis. Sukriti Baweja, Chhagan Bihari, Preeti Negi, Swati Thangariyal, Anupma Kumari, Deepika Lal, Deepanshu Maheshwari, Jaswinder Singh Maras, Nidhi Nautiyal, Guresh Kumar, Anupam Kumar, Nirupama Trehanpati, Gautam Mehta, Ashok Kumar Chaudhary, Rakhi Maiwall, Shiv Kumar Sarin. Liver International 41 (7), 1614-1628 Liver International 2021 8.9 Co-Author
24 Differential blood transcriptome modules predict response to corticosteroid therapy in alcoholic hepatitis; S Sharma, S Baweja, JS Maras, SM Shasthry, R Moreau, SK Sarin. JHEP Reports 3 (3), 100283 JHEP Reports 2021 10 Co-Author
23 Comparative phosphoproteomic analysis unravels MAPK1 regulated phosphoproteins in Leishmania donovani. P Kaur, A Anand, A Bhat, JS Maras, N Goyal.Journal of proteomics 240, 104189 Journal of proteomics 2021 3.9 Corresponding Author
22 Characterization of a Bowman–Birk type trypsin inhibitor purified from seeds of Solanum surattense. AP Herwade, SS Kasar, NR Rane, S Ahmed, JS Maras, PK Pawar,Scientific reports 11 (1), 1-10 Scientific reports 2021 5 Corresponding Author
21 Utility of N-acetylcysteine in ischemic hepatitis in cirrhotics with acute variceal bleed: a randomized controlled trial,R Maiwall, A Kumar, AS Bhadoria, A Jindal, G Kumar, A Bhardwaj, ...JS Maras, Hepatology International 14, 577-586 Hepatology International 2020 10 Co-Author
20 Hyperoxidized albumin modulates platelets and promotes inflammation through CD36 receptor in severe alcoholic hepatitis. A Bhat, S Das, G Yadav, S Chaudhary, A Vyas, M Islam, AC Gupta, ...JS Maras. Hepatology Communications 4 (1), 50-65 Hepatology Communications 2020 5.8 Corresponding Author
19 Dysregulated lipid transport proteins correlate with pathogenesis and outcome in severe alcoholic hepatitis. JS Maras, S Das, A Bhat, A Kumar Vyas, G Yadav, S Chaudhary, S Sukriti, JS Maras. Hepatology Communications 3 (12), 1598-1625 Hepatology Communications 2019 5.8 Corresponding Author
18 Cellular and functional loss of liver endothelial cells correlates with poor hepatocyte regeneration in acute-on-chronic liver failure, S Shubham, D Kumar, S Rooge, JS Maras, D Maheshwari, N Nautiyal, … Hepatology International 13, 777-787 Hepatology International 2019 10 Co-Author
17 Modification patterns of urinary albumin correlates with serum albumin and outcome in severe alcoholic hepatitis. S Das, M Hussain, JS Maras, J Kumar, SM Shasthry, S Nayak, V Arora, ..Journal of Clinical Gastroenterology 53 (6), e243-e252 Journal of Clinical Gastroenterology 2019 3.1 Co-Author
16 Maternal immunity influences vertical transmission of hepatitis B to newborns...AK Vyas, P Negi, S Patra, JS Maras, G Ramakrishna, SK Sarin, …Hepatology communications 3 (6), 795-811 Hepatology communications 2019 5.8 Co-Author
15 Extracellular vesicles from hepatitis B patients serve as reservoir of hepatitis B virus DNA. S Sukriti, MC Choudhary, JS Maras, S Sharma, S Thangariyal, A Singh, …J Viral Hepat 26, 211-214 J Viral Hepat 2019 3.8 Co-Author
14 Molecular ellipticity of circulating albumin-bilirubin complex associates with mortality in patients with severe alcoholic hepatitis.S Das, JS Maras, R Maiwall, SM Shasthry, S Hussain, S Sharma, S Sukriti, …Clinical Gastroenterology and Hepatology 16 (8), 1322-1332. e4 Clinical Gastroenterology and Hepatology 2018 11.4 Co-Second Author
13 Iron-overload triggers ADAM-17 mediated inflammation in severe alcoholic hepatitis. JS Maras, S Das, S Sharma, S Sukriti, J Kumar, AK Vyas, D Kumar, A Bhat, …Scientific reports 8 (1), 10264 Scientific reports 2018 5 First Author
12 Baseline urine metabolic phenotype in patients with severe alcoholic hepatitis and its association with outcome. JS Maras, S Das, S Sharma, SM Shasthry, B Colsch, C Junot, R Moreau, …Hepatology Communications 2 (6), 628-643 Hepatology Communications 2018 5.8 First Author
11 Microvesicles in hepatic and peripheral vein can predict nonresponse to corticosteroid therapy in severe alcoholic hepatitis. S Sukriti, JS Maras, C Bihari, S Das, AK Vyas, S Sharma, S Hussain, …Alimentary Pharmacology & Therapeutics 47 (8), 1151-1161 Alimentary Pharmacology & Therapeutics 2018 10 Co-Second Author
10 SX-Ella stent danis effectively controls refractory variceal bleed in patients with acute- on-chronic liver failure.R Maiwall, KD Jamwal, A Bhardwaj, AS Bhadoria, JS Maras, G Kumar, … Digestive Diseases and Sciences 63, 493-501 Digestive Diseases and Sciences 2018 3.5 Co-Author
9 Bioinspired engineering for liver tissue regeneration and development of bioartificial liver: a review.S Kashte, JS Maras, S Kadam.Critical Reviews™ in Biomedical Engineering 46 (5) Biomedical Engineering 2018 2 Co-Second Author
8 Pre-therapy liver transcriptome landscape in Indian and French patients with severe alcoholic hepatitis and steroid responsiveness. S Sharma, JS Maras, S Das, S Hussain, AK Mishra, SM Shasthry, …Scientific Reports 7 (1), 6816 Scientific Reports 2017 5 Co-Second Author
7 Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis.S Das, JS Maras, MS Hussain, S Sharma, P David, S Sukriti, SM Shasthry, …Hepatology 65 (2), 631-646 Hepatology 2017 17.4 Co-Second Author
6 Dysregulated iron homeostasis is strongly associated with multiorgan failure and early mortality in acute‐on‐chronic liver failure.JS Maras, R Maiwall, HC Harsha, S Das, MS Hussain, C Kumar, C Bihari, …Hepatology 61 (4), 1306-1320 Hepatology 2015 17.4 First Author
5 Reply to:“Ferritin in decompensated cirrhosis: Iron or inflammation?”.R Maiwall, JS Maras, S Kumar, SK Sarin.Journal of Hepatology 62 (2), 500-501 Journal of Hepatology 2015 30 Co-Second Author
4 Liver dialysis in acute-on-chronic liver failure: current and future perspectives.R Maiwall, JS Maras, SL Nayak, SK Sarin.Hepatology international 8, 505-513 Hepatology international 2014 10 Co-Second Author
3 Serum ferritin predicts early mortality in patients with decompensated cirrhosis.R Maiwall, S Kumar, AK Chaudhary, J Maras, Z Wani, C Kumar, A Rastogi, …Journal of hepatology 61 (1), 43-50 Journal of hepatology 2014 30 Co-Author
2 Novel nonsense mutation of ABHD5 in Dorfman–Chanarin syndrome with unusual findings: A challenge for genotype–phenotype correlation.S Aggarwal, JS Maras, S Alam, R Khanna, SK Gupta, A Ahuja.European Journal of Medical Genetics 55 (3), 173- 177 European Journal of Medical Genetics 2012 2.5 First Author
1 Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous response.R Kumar, A Rastogi, JS Maras, SK Sarin. Clinical biochemistry 45 (3), 272-274 Clinical biochemistry 2012 3.6 Co-Author

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