Research |
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Experience | ||||||||
Research focuses on elucidation of molecular pathways at cellular and systems level during disease progression using integrated analysis of genomic (total RNA, miRNA), proteomic, metabolomic and metagenomic data. An intense area of research in this regard is the gut microbial alterations during disease onset. Using the Next Generation Sequencing tools the group has analyzed the gut metagenome in patients of alcoholic liver disease. In the same set of patients, the PBMC transcriptome and plasma metabolome has also been analyzed. New tools are being devloped for identifying transcriptome modules in blood and liver, that provide insight at a system level functioning of genes/cells during disease progression. The strongholds of the lab are employing mathematical modelling for analysis of the omics data and also that it is the only unit at ILBS to perform bioinformatic analysis using R and Python, besides other tools. Another area of investigation is genetic analysis of inheritance patterns of the potential candidate genes which when mutated results in genetic disorders which finally affect the liver functioning. The group has screened affected families to identify potentially susceptible individuals by mutation analysis screening. |
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Qualification | ||||||||
Ph.d : University of Delhi, 2005 Postdoctoral Fellow : Department of Urology, Vanderbilt University, Nashville, TN, USA,Department of Microbiology, Meharry Medical College, Nashville, TN, USA,Division of Digestive Diseases, Emory University, Atlanta, GA, USA,Division of Gastroenterology and Hepatology, University of Maryland, Baltimore, MD, USA |
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Number of publications | ||||||||
25 | ||||||||
Research Int | ||||||||
The goal of the Integrated Technologies Laboratory (ITL) at ILBS is to progress the understanding of underlying mechanisms in liver diseases by employing a systemic approach. The laboratory has a rare distinction in working on molecular mechanisms from cellular (hepatocytes and others) to ecosystem levels (gut microbiome) and establishing a correlation between the two. In view of this the major areas of research involves: 1. To unravel the molecular pathways active between cells and tissues during disease progression using the “OMICS” approach. For this the group is using a comprehensive integrated approach of genomic, proteomic, metabolomic and metagenomic tools. An intense area of research in this regard is the genetic analysis of inheritance patterns of the potential candidate genes which when mutated results in genetic disorders which finally affect the liver functioning. Our group has screened affected families to identify potentially susceptible individuals by mutation analysis screening. |
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Publications | ||||||||
Details/List of Projects (Project Title, Funding Agency and Start Date) Total Number of publications in 2017: 8 |