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Speciality

Research

Dr. Nirupama Trehanpati  
Dr. Nirupama Trehanpati
Professor
 
Experience
Month and Year Title Department / Institute
09/2019 Professor Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences
03/2019 Associate Dean
12/2014 International Additional Professor Institute of Liver and Biliary Sciences
07/ 2011 Associate Professor Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences
Department of Research, Institute of Liver and Biliary Sciences
07/2008 Assistant Professor Department of Research, Institute of Liver and Biliary Sciences
02/2006 Senior Research Officer G.B. Pant Hospital
Qualification

Ph.D 1992, CCS, H.A.U, Hissar

ORCID ID: 0000-0002-6109-0033

Number of publications
118
Awards
  • Invited as Faculty in European Association for Study of Liver Diseases (EASL), at London in 2022
  • Guest Lectures at Westmead Clinical school, Faculty of Medicine, University of Sydney during the visiting scientist tenure in sep, 2018
  • Guest Lecture at Center for Research on Inflammation (CRI), INSERM University of Paris on 25th April, 2017.
  • Plenary Paper Award in AASLD 2013, USA
  • Best Paper in Viral Hepatitis Conference, Frankfurt 2013
  • Presidential Paper Award at Prestigious Hepatology meet at AASLD 2012
  • Bill and Millinda Travel Grant for the Ninth Annual Conference of Vaccine, Research, Baltimore USA. 11th May 2006. Travel Grant from HIV and Liver Diseases, Wyoming, 11th 14th Sep, 2006.
  • Best Paper in Indian society of Gastroenterology, Nov 2005
  • DST Young Scientist, 2003
  • CSIR POOL Officer, 1998-2001
  • CSIR Research Associate, 1994-1997
  • CSIR, Senior research fellow in Ph.D
  • Lady Tata Memorial Fellowship in Ph.D

Visiting Professor

  • Visiting Scientist in the Department of Pathology, The Center for Systems Immunology, School of Medicine, Case Western Reserve University, from 17th Feb-27th Feb, 2020 under the HIPC collaboration. Indo-US Project
  • Visiting Scientist in the Westmead Clinical School, Faculty of Medicine, University of Sydney from 1st-20th Sep, 2018
  • Visiting Scientist in the laboratory of Innate Immunology, NIAID National Institute of Health, Maryland, USA, in 2014
  • Visiting Scientist in the laboratory of Innate Immunology, NIAID National Institute of Health, Maryland, USA, in 2010
  • Visiting Scientist in the laboratory of Innate Immunology, NIAID National Institute of Health, Maryland, USA, in 2007
  • Visiting researcher to University of Birmingham, Liver Research Group, Division of Medical Sciences, Birmingham, 2006.
  • Visiting scholar to German Research Center for biotechnology, Braunschweig, Germany in 2005.
  • Vice-Chairperson in IC-SCR of DATT Mediproducts PVt. Ltd.

Membership

  • Member of National Academy of Medical Sciences, New Delhi
  • Life member of Indian Immunology Society
  • Life member of Indian Society of Translational Research
  • Life member of Cytometry Society
  • Life member of Indian Society of Primary Immune deficiency ISPID
  • Life Member of Indian science congress
  • Life Member of Indian Society for Histocompatibility and Immunogenetics
  • Member of Asia pacific study of Liver Diseases
Clinical Int

Dr. Trehanpati is team leader for Clinical transplant Immunology (CTI) unit at ILBS, CTI is a state of the art histo-compatibility and immune-genetics testing laboratory that supports busy clinical transplant programs and transplantation research activities.
In ILBS overarching goal of CTI unit is to provide the comprehensive diagnostic tests related to liver and kidney transplants as well as for graft rejections. In addition CTI unit is on National DNA QC Exchange Program with AIIMS, New Delhi. CTI performs investigations for determination of HLA B-27, HLA DQ2-DQ8, complement-dependent cytotoxicity, Donor Specific Antibodies, flow based assays including CD4 and CD8 ratio test for HIV and immune compromised patients, antiviral drug monitoring, Tregs, NK/NKT ratios and CD19 typing for Rituximab treatment.

Research Grants

Ongoing Research Support as Principal Investigator

Lady Tata Memorial Trust, 2023-2026: To study the efficacy of SBRT in imprioving the overall survival and tumor control by immunomodulating the tumor microenviorenment in HCC patients.

ICMR, 2022-2024: Omics-driven system interrogation of metabolomics,proteiomic, lipidomic and trancriptomic dysregulation in COVID-19 pathogenesis during pregnancy.

DBT, 2023-2026: Designing Bispecific CAR-NK Cell targeting AFP and GPC-3 in HCC

DBT, 2019-2023: Understanding the epigenetic modulation of memory and exhaustion genes in Hepatitis B Virus reactivation.

Research Int

Nirupma Trehanpati, M.Sc., Ph.D is a Professor and Faculty in charge in the department of Molecular and Cellular medicine, Institute of Liver and Biliary Sciences ( ILBS), New Delhi. She is a faculty of WHO, Collaborating Center for viral hepatitis at ILBS from 1st May, 2015. One of the key purposes of the WHO CC is to serve as a resource center for building the capacity of healthcare personnel in relation to viral hepatitis and liver diseases. She is chairperson in the Board of studies in MCM, ILBS and also served as associate dean (International) at ILBS.

Her group has been focused for the past ten years on developing a better understanding of the human immune responses in chronic hepatitis B and acute hepatitis E virus infections during pregnancy with a specific focus on neonate’s immunology. Over the past few years we have focused on immune responses in babies after HBV vaccine administration. For this, we have implemented the use of system biology approaches to monitor the B cells development and T cells exhaustion to identify the mechanisms of viral clearance or persistence of hepatitis B virus.

Our team also works on the revolutionary CAR-NK cell therapy and immunotherapy for hepatocellular carcinoma (liver cancer). She has more than twenty four years of teaching, basic and translational research experience. Till now, she has guided 19 Ph.D, DM and MCH students and published total of 116 articles and two book chapters with more than 3548 citations, since 2018 citations 2251, Total h index 32; i10 index 72, Her one article is published as editorial commentary (Liver Cancer) and one article was appeared on the cover page of the Hepatology jounal.

Trainings

Name of the conf./course/training/workshop attended:
Faculty Development Program

Publications

Research publications (Till Date) in Pubmed Format

  • 1. Ankur Vagadiya, Rashi Sehgal, Nirupma Trehanpati*, Viniyendra Pamecha*. Alterations in CD4+ T-cell subsets in living donor liver transplantation (LDLT) associated with graft rejection. 2024 April Under review in Journal of Clinical and Experimental Hepatology
  • 2. Anoushka Saxena, Minal, Prabhjyoti Pahwa, Jaswinder Singh Mars, Hamda Siddiqui, Jayesh Kumar Sevak, Y.M.Mala, Shakun Tyagi, Shiv K Sarin*, Nirupama Trehanpati*. High bilirubin induces immune-metabolic shift worsening obstetric complications in pregnancy, with or without HEV infection. Under review in Journal of Hepatology.
  • 3. Jayesh Kumar Sevak#, Mojahidul Islam#, Gayantika Verma, Anoushka Saxena, Preedia Babu E, Shahana Parveen, Ankur Jindal, Manoj Kumar Sharma, Gayatri Ramakrishna, Shiv Kumar Sarin*, Nirupama Trehanpati*. 2023. Epigenetic mediated functional reprogramming of immune cells leads to HBsAg seroconversion in Hepatitis B Virus Reactivation patients. Under review in Hepatology Communications.
  • 4. Prabhjyoti Pahwa, Ashish Kumar Vyas, Jayesh Kumar Sevak, Ravinder Singh, Jaswinder Singh Maras, Sharda Patra, Shiv K Sarin, Nirupama Trehanpati* 2023. Modulation of CD8T cells, natural killer cells and Th1 cytokines by metabolic milieu in decline of HBV viremia in pregnant women treated with Tenofovir disoproxil from second trimester of pregnancy. Journal Of Reproductive Immunology. 25th jan, 2024, https://doi.org/10.1016/j.jri.2024.104208
  • 5. Karan Kumar, Ankur Jindal, Ekta Gupta, Nirupama Trehanpati, Saggere Muralikrishna Shasthry, Rakhi Maiwall,Vinod Arora, Ankit Bhardwaj, Guresh Kumar, Manoj Kumar, Shiv K Sarin. 2023 Long term HBsAg responses to peg-interferon alpha-2b in HBeAg negative chronic hepatitis B patients developing clinical relapse after stopping long term nucleos (t) ide analogue therapy Journal of Clinical and Experimental Hepatology, 2024 14(1):101272 doi: 10.1016/j.jceh.2023.08.008.
  • 6. Khan S, Anwer A, Sevak JK, Trehanpati N, Kazim SN. Cytokines Expression Compared to the Determinants of Cellular Apoptosis Prominently Attributes to the Deleterious Effects of 'A' Determinant Surface Gene Mutations in HBV Transfected Hepatoma Cell Line. Immunol Invest. 2023 Dec14:1-17.doi: 10.1080/08820139.2023.2288841.
  • 7. Sandhya Hora, Prabhjyoti Pahwa, Hamda Siddiqui, Anoushka Saxena, Minal Kashyap, Jayesh Kumar Sevak, Ravinder Singh, Maryam Javed, Pushpa Yadav, Pratibha Kale, Gayatri Ramakrishna, Asmita Rathore, Jaswinder Singh Maras, Shakun Tyagi, Shiv kumar Sarin, Nirupama Trehanpati 2023. Metabolic alterations unravel the materno–fetal immune responses with disease severity in pregnant women infected with SARS-CoV-2. Journal Of Medical Virology 2023 Dec;95(12):e29257. Doi:10.1002/jmv.29257.
  • 8. Vikrant Sood , Bikrant B Lal, N S Ashwini, Rajeev Khanna, Viniyendra Pamecha, Nirupama Trehanpati , Seema Alam. Operational Tolerance after Liver Transplantation: First Report from India. J Clin Exp Hepatol. 2023 Jan-Feb;13(1):178-181. doi: 10.1016/j.jceh.2022.09.002.
  • 9. Arjun Maria, Rajeev Khanna, Bikrant B Lal, Vikrant Sood, Trehanpati N, Seema Alam. Association of HLA DRB1 allele profile with pediatric autoimmune liver disease in India. Journal of Clinical and Experimental Hepatology. 2023>ay-Jun;13(3):397-403, doi: org/10.1016/j.jceh.2023.01.001
  • 10. Mojahidul Islam, Jayesh Kumar Sevak, Manoj Kumar Sharma, Ankur Jindal, Ashish Kumar Vyas, Meenu Bajpai, Gayatri Ramakrishna, Shiv Kumar Sarin*, Nirupama Trehanpati. Immune predictors of Hepatitis B surface antigen seroconversion in hepatitis B reactivation Patients. Alimentary Pharmacology and Therapeutics, 2023 March;57(6):689-708. doi: 10.1111/apt.17306
  • 11. Mojahidul Islam, Karan Kumar, Jayesh Kumar Sevak, Ankur Jindal, Ashish Kumar Vyas, Gayatri Ramakrishna, Manoj Kumar Sharma, Shiv Kumar Sarin*, Nirupama Trehanpati. Immune drivers of reactivation in HbeAg Negative Chronic Hepatitis B Patients after Stopping Nucleotide Analogue Therapy. Hepatology Communication. 2023Apr 26;7(5):e0098
  • 12. Garima Garg, Meenu MN, Kajal Patel, Ravinder Singh, Priyal Gupta, Shashank Purwar, Sramana Mukhopadhyay, Nitu Mishra, Sudheer Gupta, Sumit Kumar Rawat, Harsh Goel, Rahul Kumar,Pranay Tanwar, Jitendra Singh, Shashwati Nema, Debasis Biswas, Nirupma Trehanpati, Anirudh K Singh, Ashish Kumar Vyas. Presence of entry receptors and viral markers suggest a low level of placental replication of Hepatitis B Virus in a proportion of pregnant women infected with chronic hepatitis B. Sci Rep. 2022 Oct 22;12(1):17795. doi: 10.1038/s41598-022-22699-8.
  • 13. Savera Aggarwal, Vipin Yadav, Rakhi Maiwall, Archana Rastogi, Viniyendra Pamecha, Onkar Bedi, Jaswinder Maras, Nirupma Trehanpati, Gayatri Ramakrishna. Metabolomic analysis shows dysregulation in amino acid and NAD+metabolism in palmitate treated hepatocytes and plasma of non-alcoholic fatty liver disease spectrum. Biochem Biophys Res Commun. 2023 Feb 5;643:129-138. doi: 10.1016/j.bbrc.2022.12.078. Epub 2022 Dec 28.
  • 14. Manoj Kumar , Zaigham Abbas , Milad Azami , Maria Belopolskaya , A K Dokmeci , Hasmik Ghazinyan , Jidong Jia , Ankur Jindal , Han Chu Lee , Wei Lei , Seng Gee Lim , Chun-Jen Liu , Qiang Li Mamun Al Mahtab , David H Muljono 15, Madunil Anuk Niriella Masao Omata , Diana A Payawal , Shiv K Sarin, Olivier Ségéral , Tawesak Tanwandee , Nirupma Trehanpati , Kumar Visvanathan, Jin Mo Yang , Man-Fung Yuen , Yingjie Zheng, Y H Zhou. Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy. Hepatology International. 2022 April;16(2):211-253.
  • 15. Rashi Sehgal, Rakhi Maiwall, Vijayraghavan Rajan, Mojahidul Islam, Sukriti Baweja, Navkiran kaur, Guresh Kumar, Gayatri Ramakrishna, Shiv K Sarin, Nirupama Trehanpati*. GMCSF modulates Myeloid derived suppressor cells and Tregs activity in decompensated cirrhotic patients with sepsis. Front Immunol. 2022 Jun 3;13:828949. doi: 10.3389/fimmu.2022.828949.
  • 16. Savera Aggarwal, Nirupma Trehanpati, Nagarajan P, Gayatri Ramakrishna. The Clock- NAD + - Sirtuin connection in Nonalcoholic Fatty Liver Disease. J Cell Physiol. 2022 Aug;237(8):3164-3180. doi: 10.1002/jcp.30772.
  • 17. Savera Aggarwal, Archana Rastogi, Rakhi Maiwall, Jayesh K Sevak, Vipin Yadav, Jaswinder Maras, SherinSarahThomas, Pratibha R Kale, Viniyendra Pamecha, Nagarajan Perumal, Nirupma Trehanpati, Gayatri Ramakrishna. Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD+-SIRT2 axis. Submitted in CMGH Sep 2022.
  • 18. Maheshwari D, Kumar D, Jagdish RK, Nautiyal N, Hidam A, Kumari R, Sehgal R, Trehanpati N, Baweja S, Kumar G, Sinha S, Bajpai M, Pamecha V, Bihari C, Maiwall R, Sarin SK, Kumar A. Bioenergetic failure drives functional exhaustion of monocyte in Acute-on-Chronic Liver Failure. Front Immunol. 2022 Jun 3;13:856587. doi: 10.3389/fimmu.2022.856587.
  • 19. Rashi Sehgal, Navkiran Kaur, Rakhi Maiwall, Gayatri Ramakrishna, Jaswinder Singh Maras*, Nirupma Trehanpati*. Plasma proteomic analysis identified proteins associated with faulty neutrophils functionality in decompensated cirrhosis patients with sepsis. Cells. 2022 May 25;11(11):1745. doi: 10.3390/cells11111745.
  • 20. Bijoya Sen, Savera Aggarwal, Rhisita Nath, Rashi Sehgal, Ravinder Singh, Khushboo Agrawal, Ashwini Nagaraghatta Shashidhara, Archana Rastogi, Meenu Bajpai , Viniyendra Pamecha, Nirupma Trehanpati and Gayatri Ramakrishna. 2022 Secretome of Senescent hepatoma cells modulate immune cell fate by macrophage polarization and neutrophil extracellular traps formation. Med Oncol. 2022 Jun 21;39(9):134. doi: 10.1007/s12032-022-01732-w
  • 21. Pushpa Yadav, Nirupama Trehanpati*, Rakhi Maiwall, Rashi Sehgal, Ravinder Singh, Mojahidul Islam, Rakesh Kumar Jagdish, Rajan V, Deepanshu Maheshwari, Sadam Bhat, Pratibha Kale, Anupam Kumar, Sukriti, Guresh Kumar, Gayatri Ramakrishna, Shiv K Sarin* Soluble Factors and Suppressive Monocytes can Predict the Early Development of Sepsis in Acute-on-Chronic Liver failure. Hepatology communications May 2022. doi: 10.1002/hep4.1949.
  • 22. Rakhi Maiwall , Meenu Bajpai , Akanksha Singh , Tanvi Agarwal , Guresh Kumar , Ankit Bharadwaj , Nidhi Nautiyal , Harsh Tevethia, Rakesh Kumar Jagdish , Rajan Vijayaraghavan, Ashok Choudhury , Rajendra Prasad Mathur , Ashini Hidam , Nirupama Trehanpati , Manoj Kumar Sharma , Anupam Kumar, Shiv Kumar Sarin. Standard-Volume Plasma Exchange Improves Outcomes in Patients With Acute Liver Failure: A Randomized Controlled Trial Clin Gastroenterol Hepatol. 2021 Jan 29;S1542-3565(21)00086-0. doi: 10.1016/j.cgh.2021.01.036.
  • 23. Gayatri Ramakrishna, Preedia E Babu, Ravinder Singh, Nirupma Trehanpati. Application of CRISPR-Cas9 based gene editing to study the pathogenesis of colon and liver cancer using organoids. Hepatology International 2021, Dec;15(6):1309-1317.
  • 24. Siddharth Mittal, Piyush Sinha, Shashwat Sarin, Archana Rastogi, Ekta Gupta, Meenu Bajpai, Viniyendra Pamecha*, Nirupma Trehanpati*. Impact of Human Leukocyte Antigen compatibility on outcomes of living donor liver transplantation: Experience from a tertiary care centre. Transpl Infect Dis. 2021 May 17:e13644. doi: 10.1111/tid.13644.
  • 25. Vyas AK, Lslam M, Garg G, Singh AK, Trehanpati N. Humoral immune responses and Hepatitis B Infection. Dig Dis. 2021 Jan 11. doi: 10.1159/000514274.
  • 26. Rashi Sehgal, Navkiran Kaur, Gayatri Ramakrishna, Nirupma Trehanpati*. Immune surveillance by Myeloid derived suppressor cells (MDSCs) in liver diseases. Dig Dis. 2022 Jun 22. 40(3):301-312 doi: 10.1159/000517459.
  • 27. Ravinder Singh , Hamed Hemati, Meenu Bajpai , Pushpa Yadav , Ashish Kumar Maheshwari , Suresh Kumar , Sonal Agrawal , Jayesh Kumar , Islam Md , Jaswinder Singh Mars , Gayatri Ramakrishna , Shiv K Sarin , Nirupma Trehanpati*. Sustained expression of inflammatory monocytes and activated T cells in COVID-19 patients and recovered convalescent plasma donors. Immunity Inflammation and disease 2021 Aug 6. doi: 10.1002/iid3.476.
  • 28. Tanvi Agrawal , Rakhi Maiwall , Rajan V , Meenu Bajpai , Rakesh Kumar Jagdish , Shiv Kumar Sarin and Nirupama Trehanpati. Lower blood lactate and higher circulating natural killer cells at admission predict spontaneous survival in non-acetaminophen induced acute Liver failure. Clin Immunol. 2021 Aug 19:108829. doi: 10.1016/j.clim.2021.108829.
  • 29. Anand V Kulkarni, Lovkesh Anand, Ashish Kumar Vyas, Ashok K Choudhury, Madhumita Premkumar, Apurva Pande, Nirupama Trehanpati, Jaya Benjamin, Priyanka Jain, Guresh Kumar, Yogendra Kumar Joshi, Shiv Kumar Sarin. Omega-3 Fatty Acid Lipid Emulsions are Safe and Effective in Reducing Endotoxemia and Sepsis in Acute-on-Chronic Liver Failure. J Gastroenterol Hepatol. 2021 Jul; 36(7):1953-1961. doi: 10.1111/jgh.15400.
  • 30. Pradeep Kumar, Viniyendra Pamecha, Archana Rastogi, Rajeev Khanna, Nirupma Trehanpati. Peripheral lymphocyte subsets in acute cellular rejection in living donor liver transplant (LDLT) recipients: A prospective observational study. Indian journal of transplantation. 2021, vol 13(3) 241-250.
  • 31. Gupta M, Krishan P, Kaur A, Arora S, Trehanpati N, Singh TG, Bedi O. Mechanistic and physiological approaches of fecal microbiota transplantation in the management of NAFLD. Inflamm Res. 2021 Jul;70(7):765-776. doi: 10.1007/s00011-021-01480-z. Epub 2021 Jul 1.
  • 32. Baweja S, Bihari C, Negi P, Thangariyal S, Kumari A, Lal D, Maheshwari D, Singh Maras J, Nautiyal N, Kumar G, Kumar A, Trehanpati N, Mehta G, Kumar Chaudhary A, Maiwall R, Kumar Sarin S. Circulating extracellular vesicles induce monocyte dysfunction and are associated with sepsis and high mortality in cirrhosis. Liver Int. 2021 Jul;41(7):1614-1628. doi: 10.1111/liv.14875. Epub 2021 Apr 1.
  • 33. Vyas AK, Varma V, Garg G, Gupta P, Trehanpati N. The role and delicate balance of Host Immunity in Coronavirus Disease-19. Iran J Immunol. 2021 Mar;18(1):1-12. doi: 10.22034/iji.2021.88526.1874.
  • 34. Meenu Bajpai, Suresh Kumar, Ashish Maheshwari, Karan Chabra, Pratibha Kale, Amita Gupta, Ekta Gupta, Nirupma Trehanpati, Chagan Bihari et al. Comparison of Safety and Efficacy of Convalescent Plasma with Fresh Frozen Plasma in Severe COVID-19 Patients. An Acad Bras Cienc. 2022 Sep 9;94(4):e20210202. doi: 10.1590/0001-3765202220210202. eCollection 2022.
  • 35. Meenu Bajpai, Ashish Maheshwari, Suresh Kumar, Karan Chabra, Pratibha Kale, Amita Gupta, Ekta Gupta, Nirupma Trehanpati, Chagan Bihari et al. Efficacy of convalescent plasma therapy in the patient with COVID-19. A randomised control trial (COPLA-II Trial). BMJ Open. 2022 Apr 6;12(4):e055189. doi: 10.1136/bmjopen-2021-055189.
  • 36. Gayatri Ramakrishna, Pradeep Kumar , Savera Aggarwal, Mojahidul Islam , Ravinder Singh , Rakesh K Jagdish , Nirupma Trehanpati . SARS-Cov-2 (Human) and COVID-19: Primer 2020 Hepatol Int. 2020 Apr 24;1-3. doi: 10.1007/s12072-020-10049-7.
  • 37. Onkar Bedi , Savera Aggarwal, Nirupma Trehanpati , Gayatri Ramakrishna, Ajmer Singh Grewal , Pawan Krishan. In Vitro Targeted Screening and Molecular Docking of Stilbene, Quinones, and Flavonoid on 3T3-L1 Pre-Adipocytes for Anti-Adipogenic Actions. Naunyn Schmiedebergs Arch Pharmacol. 2020 Jun 25. doi: 10.1007/s00210-020-01919
  • 38. Rashi Sehgal, Onkar Bedi and Nirupma Trehanpati. Role of Microbiota in pathogenesis and management of viral hepatitis Frontiers in Cellular and Infection Microbiology-Virus and Host. 2020 Aug. doi: 10.3389/fcimb.2020.00341.
  • 39. Hamed Hemati; Jagdeep Kaur, R.C. Sobti, Trehanpati N Inhibition of NOTCH signaling pathway chemosensitizes HCC CD133+ cells to vincristine and 5-fluorouracil through upregulation of BBC3. Biochemical and Biophysical Research Communications. 2020 May 14;525(4):941-947.
  • 40. Sehgal R, Kaur S, Shasthry SM, Agrawal T, Dwivedi V, Seth D, Ramakrishna G, Sarin SK, Trehanpati N. Natural Killer Cells Contribute to Pathogenesis of Severe Alcoholic Hepatitis by Inducing Lysis of Endothelial Progenitor Cells. Alcohol Clin Exp Res. 2020 Jan 44(1):78-86 doi: 10.1111/acer.14242.
  • 41. Bedi O, Aggarwal S, Trehanpati N, Ramakrishna G, Krishan P. Molecular and Pathological Events Involved in the Pathogenesis of Diabetes-Associated Nonalcoholic Fatty Liver Disease. J Clin Exp Hepatol. 2019 Sep-Oct;9(5):607-618. doi: 10.1016/j.jceh.2018.10.004.
  • 42. Ritu Khosla, Hamed Hemati, Archana Rastogi, Gayatri Ramakrishna, Shiv Kumar Sarin, Nirupma Trehanpati*. miR-26b-5p helps in EpCAM+ cancer stem cells maintenance via HSC71/HSPA8 and augments malignant features in HCC. Liver International. 2019 Jul 5. doi: 10.1111/liv.14188.
  • 43. Ashish Kumar Vyas, Pooja Negi, Sharda Patra, Jaswinder Singh Maras, Gayatri Ramakrishna, Shiv Kumar Sarin,* and Nirupma Trehanpati1*. Maternal Immunity Influences Vertical Transmission of Hepatitis B to Newborns. Hepatol Commun. 2019 Apr 16;3(6):795-811. doi: 10.1002/hep4.1351.
  • 44. Bijoya Sen, Archana Rastogi, Rhisita Nath, Saggere M. Shasthry, Viniyendra Pamecha, Sonika Pandey, Kapuganti J. Gupta, Shiv K. Sarin, Nirupma Trehanpati, and Gayatri Ramakrishna*. Senescent hepatocytes in decompensated liver show reduced UPRMT and its key player, CLPP, attenuates senescence in vitro. Cell Mol Gastroenterol Hepatol. 2019;8(1):73-94. doi: 10.1016/j.jcmgh.2019.03.001
  • 45. Arshi Khanam, Nirupma Trehanpati, Shiv Kumar Sarin. Increased Interleukin-23 Receptor (IL-23R) Expression is Associated with Disease Severity in Acute-on-Chronic Liver Failure. Liver International,2019 jun;39(6):1062-1070. DOI. 10.1111/liv.14015
  • 46. Ritu Khosla, Ashish Kumar Vyas, Nirupma Trehanpati. Dichotomy of Notch signalling in regulating tumor immune surveillance. Scandinavian Journal of Immunology, 2019 Mar;89(3):e12744. DOI: 10.1111/sji.12744
  • 47. Arora A, Kumar A, Anand AC, Puri P, Dhiman RK, Acharya SK, Aggarwal K, Aggarwal N, Aggarwal R, Chawla YK, Dixit VK, Duseja A, Eapen CE, Goswami B, Gujral K, Gupta A, Jindal A, Kar P, Kumari K, Madan K, Malhotra J, Malhotra N, Pandey G, Pandey U, Puri RD, Rai RR, Rao PN, Sarin SK, Sharma A, Sharma P, Shenoy KT, Singh KR, Singh SP, Suri V, Trehanpati N, Wadhawan M. Indian National Association for the Study of the Liver-Federation of Obstetric and Gynaecological Societies of India Position Statement on Management of Liver Diseases in Pregnancy. J Clin Exp Hepatol. 2019 May-Jun;9(3):383-406. doi: 10.1016/j.jceh.2019.02.007. Epub 2019 Mar 6. Review.
  • 48. Baylis SA, Hanschmann KO, Matsubayashi K, Sakata H, Roque-Afonso AM, Kaiser M, Corman VM, Kamili S, Aggarwal R, Trehanpati N, Gärtner T, Thomson EC, Davis CA, da Silva Filipe A, Abdelrahman TT, Blümel J, Terao E; HEV collaborative study group. Development of a World Health Organization International Reference Panel for different genotypes of hepatitis E virus for nucleic acid amplification testing. J Clin Virol. 2019 May 14. pii: S1386-6532(19)30115-5. doi: 10.1016/j.jcv.2019.05.006.
  • 49. Preety Rawal, Hamda Siddiqui, Mohsin Hassan, Manish Chaudhary, Dinesh M Tripathi, Vikrant Nain, Nirupma Trehanpati, Savneet Kaur Endothelial cell-derived TGF-β Promotes Epithelial-Mesenchymal Transition via CD133 in HBx-infected Hepatoma cells. Front Oncol. 2019 Apr 24;9:308. doi: 10.3389/fonc.2019.00308.
  • 50. Gupta S, Singh K, Garg A, Bhandari PS, Sah SK, Reichenberger E, Kapoor S, Jain S, Trehanpati N. Clinicoradiologic follow up of cherubism with aggressive characteristics: a series of 3 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Feb 7. doi: 10.1016/j.oooo.2019.01.082.
  • 51. Ramakrishna G, Trehanpati N. Fatty liver checkmates hepatitis B virus. Hepatol Int. 2018 Sep;12(5):387-389. doi: 10.1007/s12072-018-9903-9. Epub 2018 Oct 12.
  • 52. Vyas AK, Jindal A, Trehanpati N. Ponder the Innate Immunity in Hepatitis B Infection. Gastroenterology. 2018 Sep 14. pii: S0016-5085(18)34759-0. doi: 10.1053/j.gastro.2018.05.052.
  • 53. Sukriti Sukriti, Manish Chandra Choudhary, Jaswinder Singh Maras, Sachin Sharma, Swati Thangariyal, Avishek Singh, Sukanto Das, Mojahidul Islam, Shvetank Sharma, Nirupama Trehanpati, Ekta Gupta, Shiv Kumar Sarin Extracellular Vesicles From Hepatitis B Patients Serve As Reservoir Of Hepatitis B Virus DNA. J Viral Hepat. 2019 Jan;26(1):211-214. doi: 10.1111/jvh.12995.
  • 54. Maras JS, Das S, Sharma S, Sukriti S, Kumar J, Vyas AK, Kumar D, Bhat A, Yadav G, Choudhary MC, Sharma S, Kumar G, Bihari C, Trehanpati N, Maiwall R, Sarin SK. Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis. Sci Rep. 2018 Jul 6;8(1):10264. doi: 10.1038/s41598-018-28483-x.
  • 55. Ashish Kumar Vyas, Usha Ramakrishna, Bijoya Sen, Mojahidul Islam, Gayatri Ramakrishna, Sharda Patra, Archana Rastogi, Shiv Kumar Sarin*, Nirupma Trehanpati1*. Placental expression of Asialoglycoprotein receptor associated with Hepatitis B virus transmission from mother to child. Liver Int. 2018 38(12):2149-2158 doi: 10.1111/liv.13871.
  • 56. Savneet Kaur, Rashi Sehgal, Shastry SM, Geoffrey McCaughan, Helen McGuire, Barbara Fazekas, Shiv Sarin, Nirupma Trehanpati*, Devanshi Seth*. Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients with Alcoholic Liver Cirrhosis. Front Physiol. 2018 May 22;9:556. doi: 10.3389/fphys.2018.00556. eCollection 2018.
  • 57. Sukriti Sukriti, Jaswinder Singh Maras, Chhagan Bihari, Sukanta Das, Ashish Kumar Vyas, Shvetank Sharma, Shabir Hussain, SM Shasthry, Ashok Choudhary, Madhumita Premkumar, Dhananjay Kumar, Guresh Kumar,Chinmay Mukhopadhyay, Anupam Kumar, Nirupma Trehanpati, Pierre Emmanuel Rautou, Richard Moreau, Shiv Kumar Sarin. Microvesicles in Hepatic and Peripheral Vein can Predict Non-Response to Corticosteroid Therapy in Severe Alcoholic Hepatitis. Aliment Pharmacol Ther. 2018 Apr;47(8):1151-1161. doi: 10.1111/apt.14564. Epub 2018 Feb 20.
  • 58. Singh AK, Rooge SB, Varshney A, Vasudevan M, Bhardwaj A, Venugopal SK, Trehanpati N, Kumar M, Geffers R, Kumar V, Sarin SK. Global micro RNA expression profiling in the liver biopsies of Hepatitis B Virus infected patients suggests specific miRNA signatures for viral persistence and hepatocellular injury. Hepatology. 2018 May; 67(5):1695-1709.
  • 59. Ram BM, Dolpady J, Kulkarni R, Usha R, Bhoria U, Poli UR, Islam M, Trehanpati N, Ramakrishna G. Human papillomavirus (HPV) oncoprotein E6 facilitates Calcineurin-Nuclear factor for activated T cells 2 (NFAT2) signaling to promote cellular proliferation in cervical cell carcinoma. Exp Cell Res. 2017 Nov 9. pii: S0014-4827(17)30613-4.
  • 60. Anwar T, Sen B, Aggarwal S, Nath R, Pathak N, Katoch A, Aiyaz M, Trehanpati N, Khosla S, Ramakrishna G. Differentially regulated gene expression in quiescence versus senescence and identification of ARID5A as a quiescence associated marker. J Cell Physiol. 2018 May;233(5):3695-3712.
  • 61. Vyas AK, Khosla R, Trehanpati N.In Response to 'The role of circulating T follicular helper cells and regulatory cells in non-small cell lung cancer patients'. Scand J Immunol. 2017 Oct; 86(4):248.
  • 62. Ashish Kumar Vyas, Nirupma Trehanpati. IL-21 receptor antagonist inhibits Differentiation of B cells toward Plasmablasts upon alloantigen stimulation. Front Immunol. 2017 Aug 4;8:934. doi: 10.3389/fimmu.2017.00934.
  • 63. Ashish Kumar Vyas1, Barjesh Chander Sharma2, Shiv Kumar Sarin2, Nirupma Trehanpati1 Immune correlates of hepatitis B surface antigen spontaneous seroconversion in hepatitis B e antigen negative chronic hepatitis B patients Liver Int. 2018 Jan;38(1):38-49. doi: 10.1111/liv.13475.
  • 64. Manali Garg, Arpita Banik, Vikash Kumar, Savneet Kaur, Shiv K. Sarin, Asok Mukhopadhyay, Nirupma Trehanpati. Bone marrow endothelial progenitor cells activate hepatic stellate cells and aggravate carbon tetrachloride induced liver fibrosis in mice via paracrine factors. Cell Proliferation 2017 Aug; 50(4). doi: 10.1111/cpr.12355. Epub 2017 Jul 6
  • 65. Arshi Khanam, Nirupma Trehanpati, Peggy Riese, Archana Rastogi, Carlos Alberto Guzmán and Shiv Kumar Sarin. Blockade of Neutrophil’s Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Failure. Front Immunol. 2017 Apr 24; 8:464. doi: 10.3389/fimmu.2017.00464. eCollection 2017.
  • 66. Nirupma Trehanpati, Rashi Sehgal, Sharda Patra, Ashish Vyas, Madavan Vasudevan, Ritu Khosla, Arshi Khanam, Guresh Kumar, Rakhi Maiwall, Gayatri Ramakrishna, Shyam Kottilil, Shiv Kumar Sarin. MiRNA Signatures can predict Acute Liver Failure in hepatitis E infected pregnant females. Heliyon. 2017 Apr 6; 3(4):e00287. doi: 10.1016/j.heliyon.2017.e00287.
  • 67. Vyas AK, Jindal A, Hissar S, Ramakrishna G, Trehanpati N. Immune balance in Hepatitis B Infection: Present and Future Therapies. Scand J Immunol. 2017 Apr 7. doi: 10.1111/sji.12553.
  • 68. Vyas AK, Trehanpati N. In Response to 'Chemokine Patterns in Children with Acute Bacterial Infections'. Scand J Immunol. 2017 Mar; 85(3):235.
  • 69. Ritu Khosla, Archana Rastogi, Gayatri Ramakrishna, Viniyendra Pamecha, Ashok Mukhopadhyay, Madavan Vasudevan, Shiv Kumar Sarin, Nirupma Trehanpati. EpCAM+ liver cancer stem-like cells exhibiting autocrine Wnt signalling potentially originate in cirrhotic patients. Stem Cells Transl Med. 2017 Mar; 6(3):807-818. doi: 10.1002/sctm.16-0248.
  • 70. Nirupama Trehanpati* and Ashish Kumar Vyas. Immune regulation by T regulatory Cells in HBV related inflammation and Cancer. Scand J Immunol. 2017 Mar; 85(3):175-181. doi: 10.1111/sji.12524.
  • 71. Sharma BC, Singh J, Srivastava S, Sangam A, Mantri AK, Trehanpati N, Sarin SK. Randomized Controlled Trial Comparing Lactulose plus Albumin versus Lactulose alone for Treatment of Hepatic Encephalopathy. J Gastroenterol Hepatol. 2017 Jun; 32(6):1234-1239.
  • 72. Shah SR, Rao PN, Sarin SK, Chowdhury A, Bhatia S, Dharamsi R, Goswami BD, Kapoor D, Luaia R, Mehta R, Mukewar S, Prasad VG, Rai RR, Saigal S, Singh D, Trehanpati N, Chen S, Gaggar A, Knox SJ, Subramanian GM, Singh SP, Sood A, Varghese J, Venugopal RV. Chronic hepatitis C virus infection in India: regional demographics and distribution of viral genotypes. Indian J Gastroenterol. 2016 Nov; 35(6):469-477.
  • 73. Sukriti S, Trehanpati N, Kumar M, Pande C, Hissar SS, Sarin SK. Functionally aberrant dendritic cell subsets and expression of DC-SIGN differentiate acute from chronic HBV infection. Hepatol Int. 2016 Nov; 10(6):916-923.
  • 74. Shrivastava S, Meissner EG, Funk E, Poonia S, Shokeen V, Thakur A, Poonia B, Sarin SK, Trehanpati N, Kottilil S. Elevated hepatic lipid and interferon stimulated gene expression in HCV GT3 patients relative to non-alcoholic steatohepatitis. Hepatol Int. 2016 Nov;10(6):937-946.
  • 75. Das S, Maras JS, Hussain S, Sharma S, David P, Sukriti S, S M S, Maiwall R, Trehanpati N, Singh TP, Sarin SK. Hyperoxidized Albumin Modulates Neutrophils to Induce Oxidative Stress and Inflammation in Severe Alcoholic Hepatitis. Hepatology. 2016 Oct 24. doi: 10.1002/hep.28897. [Epub ahead of print]
  • 76. Bihari C, Anand L, Rooge S, Kumar D, Saxena P, Shubham S, Sukriti, Trehanpati N, Kumar G, Pamecha V, Sharma S, Rastogi A, Kumar A,Sarin SK. 2016. Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver. Hepatology. 2016 Oct; 64(4):1273-88. doi: 10.1002/hep.28754. Epub 2016 Aug 24.
  • 77. Shridhar Vasantrao Sasturkar, Paul David, Shreya Sharma, Shiv Kumar Sarin, Nirupama Trehanpati, Viniyendra Pamecha. Serial Changes of Cytokines and Growth Factors in Peripheral Circulation after Right Lobe Donor Hepatectomy. Transplantation, 2015 Nov 24. doi: 10.1002/lt.24373.
  • 78. Lynn B. Dustin and Nirupma Trehanpati*. 2015. Recent advances in HBV and HCV immunology. EDITORIAL Frontiers in Immunology. 2015 Sep 4; 6:453. doi: 10.3389/fimmu.2015.00453. eCollection 2015. PMID: 26388875.
  • 79. Rashi Sehgal, Sharda Patra, Paul David, Ashish Vyas, Arshi Khanam, Syed Hissar, Ekta Gupta, Guresh Kumar, Shyam Kottilil, Rakhi Maiwall, Shiv Kumar Sarin*, Nirupama Trehanpati*. Impaired monocyte-macrophage functions and defective TLR signaling in hepatitis E virus infected pregnant women with acute liver failure. Hepatology. 2015 Aug 31. doi: 10.1002/hep.28143. PMID: 26331854.
  • 80. Gayatri Ramakrishna, Bijoya Sen, Nirupma Trehanpati and Shiv K Sarin. Repurposing of metformin in liver injury: The JNK conundrum. J Hepatol. 2015 Aug 8. pii: S0168-8278(15)00535-8..PMID: 26264935.
  • 81. Sharma S, Khosla R, David P, Rastogi A, Vyas A, Singh D, Bhardwaj A, Sahney A, Maiwall R, Sarin SK, Trehanpati N*. CD4+CD25+CD 127(low) Regulatory T Cells Play Predominant Anti-Tumor Suppressive Role in Hepatitis B Virus-Associated Hepatocellular Carcinoma. Frontiers in Immunology. 2015 Feb 25; 6:49. doi: 10.3389/fimmu.2015.00049.
  • 82. Kedarisetty CK, Anand L, Bhardwaj A, Bhadoria AS, Kumar G, Vyas AK, David P, Trehanpati N, Rastogi A, Bihari C, Maiwall R, Garg HK, Vashishtha C, Kumar M, Bhatia V, Sarin SK. Combination of granulocyte colony-stimulating factor and erythropoietin improves outcomes of patients with decompensated cirrhosis. Gastroenterology. 2015 Jun; 148(7):1362-1370.e7.
  • 83. Maras JS, Maiwall R, Harsha HC, Das S, Hussain S, Kumar C, Bihari C, Rastogi A, Kumar M, Trehanpati N, Sharma S, Pandey A, Sarin SK. Dysregulated iron homeostasis is strongly associated with multi-organ failure and early mortality in acute-on-chronic liver failure. Hepatology. 2015 doi: 10.1002/hep.27636.
  • 84. Barrett L, Trehanpati N, Poonia S, Daigh L, Sarin SK, Masur H, Kottilil S. Hepatic compartmentalization of exhausted and regulatory cells in HIV/HCV-coinfected patients. J Viral Hepat. 2015 Mar; 22(3):281-8. doi: 10.1111/jvh.12291.
  • 85. Nirupma Trehanpati*, Arshi Khanam, Syed Hissar, Rashi Sehgal, Ritu Khosla , Paul David , Ashish kumar , Anupama Prashar , Ankit Bhardwaj, Shyam Kottilil and Shiv Kumar Sarin. Sequential Therapy with Tenofovir Plus Peg Interferon Enhances Innate and Adaptive Immunity Compared to Tenofovir Monotherapy in Chronic Hepatitis B Patients. J Clin Cell Immunol 2014, 5:6 http://dx.doi.org/10.4172/2155-9899.1000272.
  • 86. Arshi Khanam, Nirupama Trehanpati, Vishal Garg, Chandan Kumar, Hitendra Garg, Barjesh C Sharma and Shiv Kumar Sarin. Altered Frequencies of Dendritic Cells and IFN-c-secreting T Cells with Granulocyte Colony-Stimulating Factor (G-CSF) Therapy in Acute-on-Chronic Liver Failure. Liver International, 2014 Volume 34, Issue 4, pages 505–513.
  • 87. Rastogi A, Maiwall R, Bihari C, Trehanpati N, Pamecha V, Sarin SK. 2014. Two-tier regenerative response in liver failure in humans. Virchows Arch. 2014 May; 464(5):565-73. doi: 10.1007/s00428-014-1547-0. Epub 2014 Mar 4.
  • 88. Gupta AC, Trehanpati N, Sukriti S, Hissar S, Midha V, Sood A, Sarin SK. Interleukin-28b CC genotype predicts early treatment response and CT/TT genotypes predicts non-response in patients infected with HCV genotype 3. J Med Virol. 2014 Jan 10. doi: 10.1002/jmv.23876. IF: 20.46
  • 89. Nirupma Trehanpati, Syed Hissar, Shikha Shrivastav, Shiv K. Sarin. Immunological Mechanisms of Hepatitis B Virus Persistence in New Borns, Indian J Med Res. 2013 Nov; 138(5):700-10.
  • 90. Choudhary MC, Mishra G, Tripathi R, Gupta E, Singh T, Trehanpati N, Kazim SN, Kumar MS and Sarin SK. Hepatitis C virus subtype 3a isolate ILBSRAS8, complete genome In NCBI, 2014 ( Direct Submission).
  • 91. Gayatri Ramakrishna, Archana Rastogi, Nirupama Trehanpati, Bijoya Sen, Ritu Khosla, and Shiv K. Sarin 2013. From Cirrhosis to hepatocellular carcinoma: Newer molecular insights on inflammation and cellular senescence. Liver Cancer 2013; 2:367–383.
  • 92. Sherman AC, Nirupma Trehanpati, Brust DG, Formentini E, Falloon J, Daucher M, Davey RT, Masur H, Sarin SK, Kottilil S. 2012. "Augmentation of HBV specific cellular immunity with IL-15 and PD-1/PD-L1 Blockade in HBV and HIV/HBV patients treated with Adefovir. AIDS Res Hum Retroviruses. 2013 Apr;29(4):665-72
  • 93. Shikha Shrivastava, Nirupama Trehanpati, Shyam Kottilil, Shiv Kumar Sarin. Decline in immature Transitional B cells following Hepatitis B Vaccination in HBV Pediatr Infect Dis J. 2013 Jul;32(7):792-4.
  • 94. Shikha Shrivastava, Nirupama Trehanpati, Sharda Patra, Shyam Kottilil, Chandana Pande, Shubha Sagar Trivedi, Shiv Kumar Sarin. Increased Regulatory Tcells and Impaired Functions of Circulating CD8 T Lymphocytes are associated with viral persistence in Hepatitis B virus positive newborns. Journal of Viral Hepatitis, 2013, 20, 582–591.
  • 95. Trehanpati N, Shrivastav S, Shivakumar B, Khosla R, Bhardwaj S, Chaturvedi J, Sukriti, Kumar B, Bose S, Mani Tripathi D, Das T, Sakhuja P, Rastogi A, Bhihari C, Singh S, Gupta S, Kottilil S, Sarin SK.Analysis of Notch and TGF-β Signaling Expression in Different Stages of Disease Progression During Hepatitis B Virus Infection. Clin Transl Gastroenterol. 2012 Oct 4; 3:e23. doi: 10.1038/ctg.2012.
  • 96. Vishal Garg, Hitendra Garg, Arshi Khan, Nirupama Trehanpati, Ashish Kumar,Barjesh Chander Sharma, Puja Sakhuja, Shiv Kumar Sarin. Granulocyte colony stimulating factor mobilizes CD34+ cells and improves survival of patients with Acute on chronic liver failure. Gastroenterology. 2011 Nov 22.
  • 97. Sarin SK, Kumar M, Shrivastava S, Sinha S, Pati NT. Influence of Chronic HBV Infection on Pregnancy: a Human Model Of Maternofetal Virus Host Interactions. Gastroenterology. 2011 Aug 22.
  • 98. Ashish Kumar, Nirupma Trehanpati, Shiv Kumar Sarin. Use of Stem Cells for Liver diseases: Current Scenario. Journal of Clinical and Experimental Hepatology, 2011, Vol 1 (1), 17-26.
  • 99. Nirupma Trehanpati, Sukriti S, Robert Geffers, Syed Hissar, Peggy Riese, Tanja Toepfer, Jan Buer, David H Adams, Carlos A. Guzman, and Shiv Kumar Sarin. 2010. Gene Expression Profiles of T Cells from Hepatitis E Virus Infected Patients in Acute and Resolving Phase. J Clin Immunol. 2011 Jun; 31(3):498-508. Epub 2011 Feb 3.
  • 100. Nirupma Trehanpati, Shyam Kotillil, Syed Hissar, Shikha Shrivastava, Arshi Khanam, Siddartha K Mishra, Shiv Kumar Sarin. 2011. Circulating Tregs correlate with viral load reduction in Chronic HBV treated patients with Tenofovir Disoproxil Fumarate.J Clin Immunol. 2011 Jun; 31(3):509-20. Epub 2011 Feb 9.
  • 101. Thakur V, Nirupma Trehanpati, Guptan R C, Sarin S K. 2010. Efficacy of Shanvac-B recombinant DNA hepatitis B vaccine in health care workers of Northern India. Hepatobiliary Pancreat Dis Int, 2010 Aug; 9(4):393-7.
  • 102. Sukriti, Nirupma Trehanpati, Sujoy Bose, Syed S Hissar, Shiv Kumar Sarin. Antigen processing and presentation machinery is associated with immunotolerant state in chronic hepatitis b virus infection. Journal of Clinical Immunology, 2010 May; 30(3):419-25. Epub 2010 Mar 19.
  • 103. Nirupma Trehanpati, Robert Geffers, Sukriti, , Peggy Riese, Manoj Kumar Tanja Toepfer, Jan Buer, Carlos A. Guzman, Shiv Kumar Sarin. 2009. Gene expression signatures of peripheral CD4+T cells clearly discriminate patients with acute and chronic HBV viral infection. Hepatology. 2009 Mar; 49(3):781-90.
  • 104. K. Manohar, P V Suneetha, Sukriti, Nirupama Trehanpati, Abhishak C Gupta, Syed Hissar, Puja Sakhuja, S K Sarin. Association of IL-18 promoter polymorphism with liver disease severity in HCV infected Patients. Hepatology International, 2009, 3: 371-377.
  • 105. Sukriti, Nirupma Trehanpati, Ankur Sethi , Kireet Agrawal, Kamal Agrawal, G.T. Kumar, Manoj Kumar, A.T Kaanan, Shiv Kumar Sarin. Low levels of awareness, vaccine coverage and need for booster among health care workers in tertiary care hospitals in India. J Gastroenterol Hepatol. 2008. 23(11):1710-5.
  • 106. Nirupma TrehanPati, Sukriti, Syed Hissar, Kamal Agrawal, Rajni Rani, Shiv Kumar Sarin. Decrease in CD4+ T Lymphocyte proliferation responses and enhanced CD150 cell expression in health care workers non-responsive to HBV vaccine. Vaccine. 2007 Feb 26; 25(10):1848-55. Epub 2006 Nov 10.
  • 107. Maitra S, Sahu R, Trehan Nirupma, Garg SK, Nath P. 2007. Circannual variation in plasma vitellogenin and gonadotropin II levels in relation to annual ovarian cycle in female Cirrhinus mrigala. Aquaculture 265; 370-384.
  • 108. Meghen B, Jeffrey E W, Nirupm Trehanpati, Soumitra Ghosh, Robert L. Truitt and Bryon D. Jhonson. 2004. The T cell activation marker CD150 can be used to identify alloantigen-activated CD4+25+regulatory T cells. Cellular Immunology, vol 227(2); 129-139.
  • 109. Nirupma Pati, Valerie Schowinsky, Obrad Kokanovic, Victoria Magnuson and Soumitra Ghosh. 2004. A Comparison between SNaPshot, Pyrosequencing, and Biplex Invader SNP Genotyping Methods: Accuracy, Cost, and Throughput Journal of Biochemical and Biophysical Methods. Vol 60(1): 1-12.
  • 110. Sarita Negi, Singh SK, Nirupma Pati, Handa V, Chauhan R, Pati U. 2004. A proximal tissue-specific and a distal negative regulatory module control apo(a)gene transcription. Biochemical Journal. 1; 379(Pt 1):151-9.
  • 111. Nirupma Pati, Soumitra Ghosh, Martin J. Hessner, Huoy-Jii Khoo and Xujing Wang. 2003. Difference in Gene Expression Profiles between Human CD4+CD25+ and CD4+CD25- T cells. Ann. N. Y. Acad. Sci. 1005, 279-284
  • 112. Xujing Wang, Marty Hessner, Nirupma Pati, Sun-wei Guo and Soumitra Ghosh. 2003. Quantitative quality control in microarray experiments and the application in data filtering, normalization and false positive rate prediction. Bioinformatics, 19(11): 1341-1347.
  • 113. Vikas Handa, Mehboob-ul-Hussain, Nirupma Pati, Uttam Pati. 2002. Multiple liver specific factors bind to a 64-bp element and activate Apo(a) gene. Biochemical and Biophysical Research Communication 292: 243-249.
  • 114. Nirupma Trehan and Garg SK. 2001. Seasonal reproductive activity in the ovaries of the cirrhinus mrigala. J.Aquaculture 9; 29-43.
  • 115. Uttam Pati and Nirupma Pati. 2000. Lipoprotein (a), atherosclerosis and apolipoprotein (a) gene polymorphism. A review article: Molecular Genetics and Metabolism 71, 87-92.
  • 116. Nirupma Pati, Abdul Rouf, and Uttam pati. 1999. Simultaneous mutations (A-G and C-T) in the apo(a) promoter of individuals with low Lp(a) levels. Molecular Genetics and Metabolism 69: 165-167.
  • 117. Nirupma Pati and Uttam Pati. 1998. Paraoxonase gene polymorphism and Coronary artery disease in Indian subjects. Int. J. Cardiology 66:165-168.
  • 118. Nirupma Trehan and Ramesh Bameazi. 1995. Induction of high SCEs in normal cells by 11-12 kd plasma protein over expressed in some sleep deprived volunteers. Mutation Research 136: 191-196.

 

Book Chapters:

  • 1. Pati N, Sarin S K. 2007. Hepatitis B Infection and its management by immunotherapy. Annual review book of Ranbaxy.
  • 2. Nirupama Trehanpati1*, Dinesh Rawat2, Hamed Hemati1. 2017. Genetics of Liver Diseases book chapter in Genome Analysis and Human Health, Springer publication, ISBN: 978-981-10-4298-0.

 

Patents Filed:

  • National patent applied entitled “Identification of a micro RNA (miR-450b) as a non-invasive biomarker in pregnant women infected with Hepatitis E Virus (HEV)”. Patent No. 201711002807
  • National patent applied entitled “A Rapid test kit for estimation of serum biomarkers for identifying critically ill patients”. Patent No. 202111058675
  • National patent applied entitled” A process of activating mitochondrial protease as a novel mechanism to rejuvenate the aging hepatocytes therby mitigating decompensation of liver and inflammaging. Patent No. - 202211020468

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