My group; hepatic regenerative medicine focuses on development of regenerative therapy in liver failure with four core themes:

• Understanding the pathophysiology of regeneration failure in liver failure
• Bone- marrow liver cross-talk in liver injury and regeneration
• Development of cellular and non-cellular therapy to prevent liver injury and augment regeneration in liver failure
• Development of extra-corporeal bio-artificial liver assist device to support falling liver function in liver failure. Currently the group comprises of 7 researches (4 PhDs and 3 junior research scholar)

Total Number of publications (till date): 39

Total Number of publications in 2018: 4

Number of projects (2018) : 3

• 1. Maiwall R, Rao Pasupuleti SS, Hidam AK, Kumar A, Tevethia HV, Vijayaraghavan R, Majumdar A, Prasher A, Thomas S, Mathur RP, Kumar G, Sarin SK. A randomized-controlled trial (TARGET-C) of high vs. low target mean arterial pressure in patients with cirrhosis and septic shock. J Hepatol. 2023 Apr 21:S0168-8278(23)00229-5.
• 2. Kumar D, Maheshwari D, Nautiyal N, Shubham S, Rooge S, Anand L, Vyas A, Kumari R, Sharma S, Bihari C, Mohanty S, Maiwall R, Kumar A, Sarin SK. Defects in energy metabolism are associated with functional exhaustion of bone marrow mesenchymal stem cells in cirrhosis. Am J Stem Cells. 2022 Feb 15;11(1):12-27.
• 3. Kedarisetty CK, Kumar A, Sarin SK. Insights into the Role of Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis. Semin Liver Dis. 2021 Jan;41(1):67-78.
• 4. Yadav P, Trehanpati N, Maiwall R, Sehgal R, Singh R, Islam M, Jagdish RK, Vijayaraghavan R, Maheshwari D, Bhat S, Kale P, Kumar A, Baweja S, Kumar G, Ramakrishna G, Sarin SK. Soluble factors and suppressive monocytes can predict early development of sepsis in acute-on-chronic liver failure. Hepatol Commun. 2022 Aug;6(8):2105-2120.
• 5. Maheshwari D, Kumar D, Jagdish RK, Nautiyal N, Hidam A, Kumari R, Sehgal R, Trehanpati N, Baweja S, Kumar G, Sinha S, Bajpai M, Pamecha V, Bihari C, Maiwall R, Sarin SK, Kumar A. Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure. Front Immunol. 2022 Jun 3;13:856587.
• 6. Maiwall R, Bajpai M, Singh A, Agarwal T, Kumar G, Bharadwaj A, Nautiyal N, Tevethia H, Jagdish RK, Vijayaraghavan R, Choudhury A, Mathur RP, Hidam A, Pati NT, Sharma MK, Kumar A, Sarin SK. Standard-Volume Plasma Exchange Improves Outcomes in Patients With Acute Liver Failure: A Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2022 Apr;20(4):e831-e854.
• 7. Nautiyal N, Maheshwari D, Tripathi DM, Kumar D, Kumari R, Gupta S, Sharma S, Mohanty S, Parasar A, Bihari C, Biswas S, Rastogi A, Maiwall R, Kumar A, Sarin SK. Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction. Hepatol Int. 2021 Dec;15(6):1389-1401.
• 8. Ankur Jindal, Rakesh K. Jagdish, Anupam Kumar, Hepatic Regeneration in Cirrhosis, Journal of Clinical and Experimental Hepatology, 2021,
• 9. Maiwall R, Bajpai M, Choudhury AK, Kumar A, Sharma MK, Duan Z, Yu C, Hu J, Ghazinian H, Ning Q, Ma K, Lee GH, Lim SG, Shah S, Kalal C, Dokmeci A, Kumar G, Jain P, Rao Pasupuleti SS, Paulson I, Kumar V, Sarin SK; AARC working Party. Therapeutic plasma-exchange improves systemic inflammation and survival in acute-on-chronic liver failure: A propensity-score matched study from AARC. Liver Int. 2021 May;41(5):1083-1096.
• 10. Kedarisetty CK, Kumar A, Sarin SK. Insights into the Role of Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis. Semin Liver Dis. 2021 Jan;41(1):67-78.
• 11. Baweja S, Bihari C, Negi P, Thangariyal S, Kumari A, Lal D, Maheshwari D, Singh Maras J, Nautiyal N, Kumar G, Kumar A, Trehanpati N, Mehta G, Kumar Chaudhary A, Maiwall R, Kumar Sarin S. Circulating extracellular vesicles induce monocyte dysfunction and are associated with sepsis and high mortality in cirrhosis. Liver Int. 2021 Mar 13. doi: 10.1111/liv.14875
• 12. Shubham S, Kumar D, Rooge S, Maras JS, Maheshwari D, Nautiyal N, Kumari R,Bhat A, Kumar G, Rastogi A, Kumar S, Pamecha V, Maiwall R, Bihari C, Kumar A, Sarin SK. Cellular and functional loss of liver endothelial cells correlates with poor hepatocyte regeneration in acute-on-chronic liver failure. Hepatol Int. 2019 Nov;13(6):777-787.
• 13. Bihari C, Lal D, Thakur M, Sukriti S, Mathur D, Patil AG, Anand L, Kumar G,Sharma S, Thapar S, Rajbongshi A, Rastogi A, Kumar A, Sarin SK. Suboptimal Level of Bone-Forming Cells in Advanced Cirrhosis are Associated with Hepatic Osteodystrophy. Hepatol Commun. 2018 Sep 4;2(9):1095-1110.
• 14. Anand L, Bihari C, Kedarisetty CK, Rooge SB, Kumar D, Shubham S, Kumar G, Sahney A, Sharma MK, Maiwall R, Kumar A, Sarin SK. Early cirrhosis and a preserved bone marrow niche favour regenerative response to growth factors in decompensated cirrhosis. Liver Int. 2019 Jan;39(1):115-126.
• 15. Nigam N, Bihari C, Lal D, Rastogi A, Kumar S, Pamecha V, Kaur S, Kumar A, Sarin SK. Donor CD163 and nestin-positive cells predict graft function in living donor liver transplant. Clin Transplant. 2018 Mar;32(3):e13197.
• 16. Damania A, Kumar A, Teotia AK, Kimura H, Kamihira M, Ijima H, Sarin SK, Kumar A. Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems and Implantable Liver Constructs.ACS Appl Mater Interfaces. 2018 Jan 10;10(1):114-126.
• 17. Damania A, Kumar A, Sarin SK, Kumar A. Optimized performance of the integrated hepatic cell-loaded cryogel-based bioreactor with intermittent perfusion of acute liver failure plasma. J Biomed Mater Res B Appl Biomater. 2018 Jan;106(1):259-269.
• 18. Damania A, Hassan M, Shirakigawa N, Mizumoto H, Kumar A, Sarin SK, Ijima H, Kamihira M, Kumar A. Alleviating liver failure conditions using an integrated hybrid cryogel based cellular bioreactor as a bioartificial liver support. Sci Rep. 2017 Jan 12;7:40323.
• 19. Bihari C, Anand L, Rooge S, Kumar D, Saxena P, Shubham S, Sukriti, Trehanpati N, Kumar G, Pamecha V, Sharma S, Rastogi A, Kumar A, Sarin SK. Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver. Hepatology. 2016 Aug 3. doi: 10.1002/hep.28754.
• 20. Bihari C, Rastogi A, Shasthry SM, Bajpai M, Bhadoria AS, Rajesh S, Mukund A, Kumar A, Sarin SK. Platelets contribute to growth and metastasis in hepatocellular carcinoma. APMIS. 2016 Sep;124(9):776-86.
• 21. Jain E, Damania A, Shakya AK, Kumar A, Sarin SK, Kumar A. Fabrication of macroporous cryogels as potential hepatocyte carriers for bioartificial liver support. Colloids Surf B Biointerfaces. 2015 Dec 1;136:761-71.
• 22. Kedarisetty CK, Anand L, Khanam A, Kumar A, Rastogi A, Maiwall R, Sarin SK. Growth factors enhance liver regeneration in acute-on-chronic liver failure. Hepatol Int. 2014 Sep;8 Suppl 2:514-25.
• 23. Bihari C, Rastogi A, Saxena P, Kumar A. Loss of S-100-positive Schwann cells is a feature of JAK2 V617F-positive myeloproliferative neoplasm. Ann Hematol. 2015 Aug;94(8):1427-9
• 24. Maiwal R, Kumar A, Sarin SK. Liver regeneration during acute-on-chronic liver failure using growth factors: in vivo or ex vivo indulgence of bone marrow? Gastroenterology. 2013 Oct;145(4):901-4.
• 25. Li DQ, Nair SS, Ohshiro K, Kumar A, Nair VS, Pakala SB, Reddy SD, Gajula RP, Eswaran J, Aravind L, Kumar R. MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Cell Rep. 2012 Dec 27;2(6):1657-69.
• 26. Kumar A, Xu J, Sung B, Kumar S, Yu D, Aggarwal BB, Mehta K. Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells. BreastCancer Res. 2012 Jan 6;14(1):R4.
• 27. Kumar A, Gao H, Xu J, Reuben J, Yu D, Mehta K. Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells. PLoS One. 2011;6(6):e20701. )
• 28. Kumar A, Xu J, Brady S, Gao H, Yu D, Reuben J, Mehta K. Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells. PLoS One. 2010 Oct 12;5(10):e13390.
• 29. Mehta K, Kumar A, Kim HI. Transglutaminase 2: a multi-tasking protein in the complex circuitry of inflammation and cancer. Biochem Pharmacol. 2010 Dec 15;80(12):1921-9. Epub 2010 Jun 25. Review.
• 30. Kumar Anupam, Molli PR, Pakala SB, Nguyen TM, Rayala SK, Kumar R. PAK thread from amoeba to mammals. J Cell Biochem. 2009 Apr 6. [Epub ahead of print]
• 31. Kumar Anupam, Chatopadhyay T.K., Raziuddin M, and Ralhan Ranju. Discovery of Deregulation of Zinc homeostasis and its associated genes in Esophageal Squamous Cell carcinoma using cDNA microarray. Int. J. Cancer , 2007; 120: 230-242
• 32. Kumar Anupam, Chatopadhyay T.K. Nootan Kumar Shukla, Sidharth Dutta Gupta and Ralhan Ranju Loss of DOC-2/Dab-2 expression in progression of esophageal squamous cell carcinoma. World Journal of Gastroenterology 2006 ; 37: 6041-45
• 33. Ralhan R, Chakravarti N, Kaur J, Sharma C, Kumar Anupam, Mathur M, Bahadur S,Shukla NK, Deo SV. Clinical significance of altered expression of retinoid receptors in oral precancerous and cancerous lesions: relationship with cell cycle regulators. Int J Cancer. 2006; 118:1077-89.
• 34. Soni S, Kaur J, Kumar Anupam, Chakravarti N, Mathur M, Bahadur S, Shukla NK, Deo SV, Ralhan R. Alterations of rb pathway components are frequent events in patients with oral epithelial dysplasia and predict clinical outcome in patients with squamous cell carcinoma. Oncology. 2005; 68: 314-25.
• 35. Kumar Anupam, Kaur J, Chattopadhyay TK, Mathur M, Ralhan R. Differential expression of retinoic acid receptors in normal and malignant esophageal tissues. J Exp Ther Oncol. 2004; 4: 1-8.
• 36. Mukherjee T, Kumar Anupam, Mathur M, Chattopadhyay TK, Ralhan R Ets-1 and VEGF expression correlates with tumor angiogenesis, lymph node metastasis, and patient survival in esophageal squamous cell carcinoma. J Cancer Res Clin Oncol. 2003; 129: 430-6.

Book Chapters: -

• 37. Anupam kumar, Cell Therapy in liver Diseases; Regenerative Medicine: Laboratory to Clinic; Springer Nature Singapore 2017.
• 38. Anupam Kumar; Stem Cell and hepatic Regeneration; Textbook of Biochemistry, Biotechanology, Allied and Molecular Medicine (Fourth Edition) 2016;
• 39. S. K. Sarin, Ashok Choudhary, Rakhi Maiwall Anupam Kumar; Treatment of ACLF (From artificial liver device to stem cells); Therapy in Liver Disease; Elsevier; 2015