PROCEDURAL SKILLS:

• Cellular Imaging (Immunofluorescence)
• Mammalian Cell Culture

• Ageing and Liver Disease
• Genetics of Liver Disease and Cancer

Research Work

• Senescence and Liver Disease
• Sirtuins, Circadian Rhythm in Fatty Liver Disorder
• Genetics of Hepatocellular Carcinoma , Gall Bladder Disease and Alcohol Usage Disorder

• Aggarwal S, Yadav V, Maiwall R, Rastogi A, Pamecha V, Bedi O, Maras JS, Trehanpati N, Ramakrishna G*. Metabolomic analysis shows dysregulation in amino acid and NAD+ metabolism in palmitate treated hepatocytes and plasma of non-alcoholic fatty liver disease spectrum. Biochem Biophys Res Commun. 2023 Feb 5;643:129-138. doi: 10.1016/j.bbrc.2022.12.078. Epub 2022 Dec 28. PMID: 36603530.
• Sen B, Aggarwal S, Nath R, Sehgal R, Singh R, Agrawal K, Shashidhara AN, Rastogi A, Bajpai M, Pamecha V, Trehanpati N, Ramakrishna G*. Secretome of senescent hepatoma cells modulate immune cell fate by macrophage polarization and neutrophil extracellular traps formation. Med Oncol 39, 134 (2022). https://doi.org/10.1007/s12032-022-01732-w
• Aggarwal S, Trehanpati N, Nagarajan P, Ramakrishna G*. The Clock-NAD⁺ -Sirtuin connection in nonalcoholic fatty liver disease. J Cell Physiol. 2022 May 26. doi: 10.1002/jcp.30772.
• Ramakrishna G ^*, Babu PE, Singh R, Trehanpati N. Application of CRISPR-Cas9 based gene editing to study the pathogenesis of colon and liver cancer using organoids. Hepatol Int. 2021 Dec;15(6):1309-1317.
• Rastogi A, Maiwall R, Ramakrishna G, Modi S, Taneja K, Bihari C, Kumar G, Patil N, Thapar S, Choudhury AK, Mukund A, Pamecha V, Sarin SK. Hepatocellular carcinoma: Clinicopathologic associations amidst marked phenotypic heterogeneity. Pathol Res Pract. 2021 Jan;217:153290.
• Ramakrishna G*, Kumar P, Aggarwal S, Islam M, Singh R, Jagdish RK, Trehanpati N. SARS-Cov-2 (human) and COVID-19: Primer 2020. Hepatol Int. 2020 Jul;14(4):475-477. doi: 10.1007/s12072-020-10049-7. Epub 2020 Apr 24. PMID: 32333304; PMCID: PMC7180666.
• Sen B, Rastogi A, Nath R, Shasthry SM, Pamecha V, Pandey S, Gupta KJ, Sarin SK, Trehanpati N, Ramakrishna G*. Senescent Hepatocytes in Decompensated Liver Show Reduced UPR^MT and Its Key Player, CLPP, Attenuates Senescence In Vitro. Cell Mol Gastroenterol Hepatol. 2019;8(1):73-94. doi: 10.1016/j.jcmgh.2019.03.001. Epub 2019 Mar 13. PMID: 30878663; PMCID: PMC6520637.
• Ramakrishna G*, Trehanpati N. Fatty liver checkmates hepatitis B virus. Hepatol Int. 2018 Sep;12(5):387-389. doi: 10.1007/s12072-018-9903-9. Epub 2018 Oct 12. PMID: 30315393.
• Ram BM, Dolpady J, Kulkarni R, Usha R, Bhoria U, Poli UR, Islam M, Trehanpati N, Ramakrishna G*. Human papillomavirus (HPV) oncoprotein E6 facilitates Calcineurin-Nuclear factor for activated T cells 2 (NFAT2) signaling to promote cellular proliferation in cervical cell carcinoma. Exp Cell Res. 2018 Jan 1;362(1):132-141. doi: 10.1016/j.yexcr.2017.11.010. Epub 2017 Nov 9. PMID: 29129565.
• Anwar T, Sen B, Aggarwal S, Nath R, Pathak N, Katoch A, Aiyaz M, Trehanpati N, Khosla S, Ramakrishna G*. Differentially regulated gene expression in quiescence versus senescence and identification of ARID5A as a quiescence associated marker. J Cell Physiol. 2018 May;233(5):3695-3712. doi: 10.1002/jcp.26227. Epub 2017 Dec 4. PMID: 29044508.