The major interests of the laboratory are:
1) Making functional and transplantable ‘hepatocyte like cells’ from various cell types, especially induced pluripotent stem cells and embryonic stem cells
2) Gene crafting using various genome editing tools, viral vectors, transposons etc.
3) Regeneration of the liver, especially the metabolomics and proteomics during the course of regeneration and termination.
Studying liver regeneration in living donor liver transplantation (LDLT) will help us design better cell culture environments which would facilitate the generation and maintenance of hepatocytes which might engraft better upon transplantation, bridging the bench to bedside. We are also interested in the events that are involved in early development in mammals, how one cell becomes another, the gain and loss of cellular identity.