Hepatology

Hepatology

Our mission is to develop Hepatology as a comprehensive discipline of medicine which can provide distinctly advanced and protocol based patient care, training and clinical and translational research. The Hepatology department at ILBS provides emergency and elective management to patients with liver, biliary and pancreatic diseases by a highly specialized and dedicated team of faculty, residents and supportive staff. With a rigorous academic program and constant monitoring and mentoring, the department is able to provide protocol and evidenced based care to an increasing number of difficult to treat patients.

The department has initiated efforts to promote the study of Hepatobiliary Sciences as a super-specialty and initiated advanced training in the field of Hepatology and Transplant Hepatology.

Adult Hepatology Services: Diagnosis and treatment of viral hepatitis (Hepatitis B, C, E, A and D), alcoholic liver disease, fatty liver disease, auto-immune hepatitis, drug hepatitis, and all causes of jaundice. Gall stones and bile duct stones; pancreatic diseases; Liver, gall bladder and GI cancers. The following specialized services are being routinely provided at hepatology department:

A). Liver Intensive Care:

The institute has established one of the finest liver intensive and critical care services with specialized rapid response teams.

At ILBS, there has been an ever increasing referral of patients for management of these emergencies as shown in the figure below.

aclf

Abbreviations: AGB: Acute GI Bleed; HE: Hepatic encephalopathy; ALF: Acute liver failure; ACLF: Acute on Chronic liver failure.

  • Acute G I Bleeds: Patients with acute GI bleed are seen immediately in the emergency room and appropriate treatment including emergency endoscopies (24x7) are instituted urgently, which leads to an improvement in survival. Patients who fail the combination of endotherapy and vasoactive agents are taken up for portal pressure (HVPG) measurement and if indicated, for emergency TIPS procedure. There is a dedicated team available round the clock for all these procedures.

  • Hepatic coma: Hepatic encephalopathy is the occurrence of confusion, altered level of consciousness, and coma as a result of liver failure. It may ultimately lead to death. A substantial increase in the patients admitted with hepatic coma occurred in the past one year. These patients are managed based on standard protocols and with our state of the art hepatic coma ICU functioning according to world standards the mortality has been reduced substantially in our ICU.

  • Acute Liver failure: Acute liver failure is the appearance of  hepatic encephalopathy rapidly after jaundice, and indicates that the liver has sustained severe damage . Common causes include Hepatitis E, Hepatitis A, and drugs. ILBS has been involved in treatment of ALF patients with a rapid response team working round the clock and with the availability of urgent liver tranplantation the outlook of this disease has improved substantially.

  • Acute on Chronic Liver failure[ACLF]:Liver failure can develop either acutely in the absence of any pre-existing liver disease[ i.e. acute liver failure or ALF] or as acute on chronic liver failure (ACLF) which denotes a sudden deterioration of known or unknown chronic liver disease patient, which can be life threatening and requires intensive ICU care. This entity was first defined in India and ILBS has henceforth carried intensive research in this disease and developed effective treatments for this deadly condition.

  • Liver dialysis : Artificial liver support systems can be non-cell based or cell-based systems. Several non-cell based extracorporeal liver support systems like hemodialysis, hemofiltration, plasma exchange, charcoal perfusion have been used in the past with a goal to remove the putative toxins and inflammatory cytokines to allow additional time for the liver to recover or as a bridge to liver transplantation. However, in all these protein bound toxins are removed to only a minor extent.
  • Single pass albumin dialysis (SPAD) , molecular absorbent and recirculation system (MARS) and recently, Prometheus (FPSA–fractional plasma separation and adsorption) which remove both water soluble and protein bound toxins have emerged as liver support therapies in patients with acute and acute on chronic liver failure. Due to the relatively small pore size of the high-flux membranes used, passage of large albumin molecules is hindered, while smaller compounds diffuse freely through the membrane. Substances with a molecular weight of more than 50 Kd are not removed because of the small pore size of the MARS membrane. In 1999, Falkenhagen et al. introduced fractionated plasma separation and adsorption (FPSA). In this system a special albumin-permeable filter with a cut-off of approximately 250,000 Dalton (250 kD) is used. Thus albumin and the protein-bound toxins pass through the membrane and are then directly removed from the blood by special adsorber within the secondary circuit. The Prometheus system which combines the FPSA method with high-flux hemo-dialysis (of the blood) in an extracorporeal detoxification system.
     
    annual annual


    annualThese newer developing therapies have demonstrated benefits in biochemical parameters, systemic hemodynamics, hepatic encephalopathy and also renal functions but are expensive and enough data is available on safety of these devices. They can be used as a bridge for spontaneous recovery or transplantation in patients with ALF. In patients with acute on chronic liver failure (ACLF) with hepatorenal syndrome or hepatic encephalopathy (without contraindications for transplantation )- to improve their chances to be listed and transplanted.

    We at ILBS have the Prometheus system, the first of it’s kind in India.

    We at ILBS are also trying to develop our “bioartificial liver” with extracorporeal bioreactors containing hepatocytes which can provide additional synthetic and biotransformatory liver functions, which may be more effective than completely artificial systems like Prometheus which provide excretory capacity alone.

B). Viral Hepatitis (A,B,C,E) and Hepatocellular Carcinoma Services:

hepbclivercancer

  • Hepatitis C virus, transmitted through blood or body fluids, leads to liver disease, which can range in severity from a mild illness lasting a few weeks to a serious, lifelong condition that can lead to cirrhosis of the liver or liver cancer. About 170 million people are chronically infected and more than 350 000 people die every year. In India alone, about 12 million people suffer from it and majority need treatment.
  • Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus. It is a major global health problem and can cause chronic liver disease and liver cancer. More than 240 million people have chronic (long-term) liver infections, and about 600 000 people die every year due to HBV. In India the prevalence is about 3-4 percent, with 40 million being infected and a large number requiring treatment.
  • Liver cancer also known as Hepatocellular carcinoma (HCC) is one of the common cancers in India.  It has been observed that besides the hepatitis B and C, the commonest cause of liver cancer is fatty liver disease, diabetes and alcohol.
  • ILBS sees one of the  largest referrals for hepatitis B,C and Liver cancer as shown in figure below.

C). Fibroscan (liver stiffness and fat measurement):

Early diagnosis and intervention can lead to a substantial reduction in morbidity and mortality from all conditions that lead to cirrhosis. Liver stiffness is important for evaluating the stage of liver fibrosis.
The transient elastograpy (FibroScan®) technique measures the liver stiffness. This is used to quantify hepatic fibrosis in a totally non-invasive and painless manner,with no contra-indications for the patients.
FibroScan allows accurate assessment of liver fibrosis resulting from all chronic pathologies that cause damage to the liver, including metabolic syndrome and non-alcoholic fatty liver disease, chronic viral hepatitis and excess alcohol intake.  In the early stages of liver disease tests and conventional ultrasound have a poor predictive value in assessing fibrosis. The FibroScan is the ideal diagnostic tool to accurately identify liver fibrosis and fat quantification.

fibroscan

D). Endoscopy Services:

There was a substantial increase in the endoscopy work as compared to previous years.
At ILBS we provide comprehensive endoscopic services- both diagnostic and therapeutic. Our spacious endoscopy suite has seven fully equipped rooms- two for gastroscopy, one for colonoscopy, one each for endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS), cholangioscopy, Intraductal ultrasound. one balloon enteroscopy room, and one room for extra-corporeal shock wave lithotripsy (ESWL). Experienced nurses and anesthesiologists receive all patients in a spacious reception area, where they are assessed pre-procedure. All elective endoscopic procedures at ILBS are carried out with tailored sedation provided by consultant anesthesiologists. Patients undergoing prolonged procedures, and high-risk patients are administered general anesthesia with elective endotracheal intubation and ventilation. After the procedures, patients are monitored in a segregated post-procedure observation area with full monitoring facilities and privacy.

We have a round–the-clock gastrointestinal bleeding service and a round the clock, GI Bleed unit with consultant endoscopists on 24-hour call. The highlights of the gastrointestinal bleeding service include a fully equipped ambulance with on-site resuscitation facilities, to triage at admission, and all endoscopic therapeutic procedures. These include variceal banding and injection, glue injection, thermal coagulation, argon plasma coagulation (APC), and hemostatic metallic stent implantation,Dennis Ela stent placement. We take pride in having a short ‘door to endoscopy’ time, which is unrivalled by any other hospital.

Our interventional radiology services work in tandem, and provide salvage angioembolization, TIPS and BRTO services for difficult to control or inaccessible bleeding sources. ILBS has one of the largest experiences in emergency TIPS stent placement. All patients with gastrointestinal bleeding are managed in an intensive care setting.

We provide comprehensive pancreato-biliary endoscopy services. These include Extra-corporeal shock wave lithotripsy (ESWL) to fragment pancreatic and bile duct stones, therapeutic ERCP, and diagnostic and therapeutic endoscopic ultrasound (EUS) procedures. We have the experience of one of the highest EUS procedures done in the country. All our EUS procedures are done under anesthesia, providing unsurpassed patient comfort and safety. We are the one of the center to have dedicated on-site cytopathology services, with EUS sampling adequacy rates exceeding 97%.We have already introduced cholangioscopy in the last quarter of 2014  for indeterminate biliary strictures and large difficult common bile duct stones. In the coming year we plan to introduce cholangioscopy, 3-D EUS, contrast-EUS, and intraductal ultrasound (IDUS) services.

The goal of endoscopy services at ILBS is amalgamation of cutting edge technology with a humane touch.  We strive to make endoscopy a pleasant experience for all patients, with attention to small details including lockers for personal belongings, clean clothes and towels, clean toilet facilities, and post-procedure discussion of the findings. Our smiling and pleasant staff is trained to put patient apprehensions at ease.

There is ever increasing load of Endoscopic Procedures  through the years as shown in figures below.

endoer1
endoser2
endoser3

Abbreviations: Capsule E: Capsule endoscopy; SVE: Side-viewing endoscopy, EUS FNAC: Endoscopic ultrasound guided fine needle aspiration


therapeutic

Abbreviations: EVL: Endoscopic variceal ligation; APC: Argon plasma laser coagulation; HP: Heater probe; Glue: Glue injection; ERCP: Endoscopic retrograde chlolangiopancreatography, Others include Extra-corporeal shock wave lithotrypsy, Polypectomy and Achalasia Dilatation

E). Hepatic Hemodynamic Laboratory:

The hepatic hemodynamic laboratory is the back bone of Hepatology services. It provides detailed insight into the liver pressure which determines the outcome of patients with liver disease. The management of patients of liver disease is based on reduction in complications (such as variceal bleed, development of ascites and renal failure) and an opportunity to regenerate the liver. All this is done in a protocol and outcome based manner at the ILBS. Measurement of the hepatic venous pressure gradient (HVPG) is currently the best available method to evaluate the presence and severity of portal hypertension. Normal HVPG is <5 mm Hg and an HVPG >10 mm Hg (termed ‘clinically significant portal hypertension’ or CSPH) predicts the development of various complications of cirrhosis. Importantly, HVPG above 12 mmHg is the threshold level for variceal rupture and a reduction of HVPG to <12 mmHg or by 20% of baseline considerably reduces the risk of bleeding, mortality and other complications of cirrhosis, such as spontaneous bacterial peritonitis and hepatic encephalopathy. As per global guidelines, sequential HVPG measurements, are helpful to optimize drug therapy or switch to another form of therapy. The main advantages of the hepatic vein catheterization technique are its simplicity, reproducibility, and safety. Since its result has important implications, the appropriate and correct measurement of HVPG is an important issue both in research and clinical practice.

Because of its relatively invasive nature and domain skills, this facility is available in very few centers in the world. We at ILBS regularly perform this procedure taking due precautions that all the steps are performed accurately.

hepatic

hepatichemodynamic

F). Quantitative Liver Functions Tests

At ILBS we have been able to standardize and establish two tests of quantitative liver functions, Indo-cyanin green (ICG)and  13C-Methacetin Breath Test (MBT). The MBT is a non-invasive, real-time molecular correlation spectroscopy assay which measures in expired breath, the abundance of 13C02 produced by hepatic cytochrome P450 metabolism of ingested non-radioactive 13C isotope-labeled methacetin, an acetaminophen precursor. MBT has been shown to assess the degree of derangement of liver metabolism in cirrhotics and preliminary data suggests that it correlates with the severity of portal hypertension (PHT). We at ILBS, performed a pilot study on 28 patients of cirrhosis due to various etiologies to investigate if MBT correlates with HVPG. MBT Cumulative PDR30 (Percent Dose Recovered at 30 min.) was the best variable and correctly detected CSPH, with an AUROC of 0.94 p<0.0001 irrespective of etiology of cirrhosis. Also, the PDR value of 13C-methacetin metabolites (i.e. breath 13C02) 30 minutes post-ingestion (PDR30), correlated with the degree of portal hypertension and HVPG (r=-0.54, p=0.0027).  Thus, it was concluded that  MBT can be recommended as a valuable non-invasive surrogate marker for the assessment of clinically significant PHT.

breathid

G). Clinical Nutrition

Department of Clinical Nutrition was established in ILBS, in 2012.The department is committed to providing nutrition support to the patients, along with nutrition education and research in collaboration with all the other departments at ILBS. Services for a detailed assessment of the nutritional status along with the body composition analysis using a bioelectrical impedance analysis system are provided by the department. Specialized enteral nutrition formulations have also been initiated for the patients. Several nutrition related research projects are underway for the partial fulfilment of the degree of DM and MCh students. The department plans to expand its services in the coming years by providing academic leadership in clinical nutrition through a well established nutrition support team, nutrition laboratory, advanced research along with education & training in the field of clinical nutrition.

 

H). Liver regeneration and stem cell therapy

Potential of stem cells to differentiate into multiple cell lineages raises the exciting possibility that these cells can be used in repair and liver regeneration, when resided stem cells are not sufficient for the regeneration of a failing liver.

During liver regeneration, bone marrow-derived hematopoietic stem cells (HSC) may mobilize to the liver and, together with hepatocytes and intrahepatic stem cells, contribute to the proliferation of liver cells. Growth factors including granulocytecolony stimulating factor (G-CSF) and erythropoetin has been used successfully at ILBS to mobilize stem cells to the periphery in patients with advanced cirrhosis and ACLF and shown survival benefit in a subgroup  of these patients.

I). Transplant Hepatology

The transplant Hepatology team works collaboratively with the transplant surgeons in the selection and care of liver transplant recipients and donors. The transplant Hepatology tem has specialized training in the management of patients with end-stage liver disease, pre- and postoperative care of transplant patients, and in the use of immunosuppressive therapy, including the sides effects of the drugs and the complications of immunosuppression.

 

J). Protocol based treatment

For patients with acute on chronic liver failure (ACLF), portal hypertension and variceal bleeding, hepatitis B and C and non-alcoholic steatohepatitis (Fatty liver disease), the department has been able to standardize the treatment protocols.

K). Patient support services

For patients with hepatitis B and C, and portal hypertension, highly skilled and trained nurses are now available to monitor the patient treatment and outcomes.

 

L). 24*7 Emergency Observation and Management Services (HEOMS)

The emergency services are functional round the clock on all days from the inception of the institute. However, due to extreme pressure on admissions of sick patients, in the last quarter of 2014, ILBS started to admit patients in the ER till the patient gets stabilized to come to OPD or gets a bed in the hospital.
The emergency unit is fully equipped with advance monitoring and resuscitation equipments. Services are well organized with dedicated manpower and adequate space for triage, observation and admission. The emergency block consists of a Triage Hall having 4 beds and an emergency observation ward with 6 beds.  START and Jump-Start Protocols are used for initial triaging of adult and pediatric patients respectively.  
The emergency services cater to all types of patients presenting with hepato biliary and non-hepato biliary conditions across all age groups. However, non-hepato biliary cases are referred to appropriate health care facilities after initial assessment and stabilization. ILBS has in house blood bank and laboratories, providing emergency support to appropriate patients.

ILBS emergency is well prepared to handle serious patients such as Acute Liver Failure (ALF) suitable for emergency transplant surgeries. A team is also ready for retrieval and transport of organs from potential brain dead donors for cadaver transplant.

 

Expert Team

A dedicated team comprising skilled emergency physicians, hepatologists, hepato-biliary surgeons and critical care specialists, is available round the clock. There is in- house presence of supporting services of pediatric hepatologists, nephrology, neurology, cardiology, urology and renal transplantation and Intervention Radiology.

Code Blue Team

Code Blue Team is available round the clock to tackle any medical emergency  involving cardiovascular arrest within the hospital premises. All activities are continually standardized through NABH accreditation program with all emergency      staff being ACLS trained.

 

Liver Helpline

A dedicated 24 hour toll free no.1-800-11-5354 has been designated as “Liver Help Line” for the benefit of patient and their relatives. Questions related to liver diseases are answered round the clock by hospital emergency staff at this telephone number. Liver helpline also functions as telephone triage service and depending upon the urgency it helps patients and their relatives directed towards seeking appropriate level of health care.

Ambulance Service

ILBS is well equipped for handling transportation of sick patients with two basic and one advanced life support ambulances. The BLS ambulances are equipped with an oxygen cylinder, and emergency medications and supplies.

The advanced “Liver Ambulance Service”, an ALS facility, is available for critically ill patients and the management of such patients is undertaken during the process of transfer to the ILBS.  This ambulance is fitted with the state of the art pre hospital medical equipment almost identical to the Hospital's ICU's. The ambulance has the capability to establish and maintain a patient's airway, defibrillate the heart, stabilize pneumothorax conditions and perform other advanced life support procedures or services, such as cardiac (EKG) monitoring, intubations and ventilation. This ambulance can transport ventilator- supported patients on long distances.

Emergency of ILBS also facilitates transfers through air ambulances for patients from far and remote places.

Disaster Management Plan

ILBS hospital has a well documented Disaster Management Plan.  ILBS is well equipped to handle any type of external or internal disaster. A documented disaster management policy is in place with clearly described roles and responsibilities.In case of Mass Casualties, the area immediately outside the emergency ward is used as a triage zone and the inner zones become designated as Yellow, Red and Black zones respectively. Disaster drills are carried out a regular interval to check preparedness.

dmp

Training and CME

Regular training programs are conducted for BLS and ACLS certification. Resident doctors, casualty medical officers, nurses and technicians have regular access to high quality clinical CMEs at the institute.

Services 2015 January’16 to November’16
Emergency care services 6890 7650
OPD services 46081 56839
ICU admissions 570 592
HDU admissions 262 270
Ward Admissions 2548 3033
Upper GI Endoscopy diagnostic 6898 7324
Upper GI Endoscopy therapeutic 2350 2567
Colonoscopy diagnostic 1540 1652
Colonoscopy therapeutic 55 67
ERCP 760 780
EUS diagnostic 500 502
EUS therapeutic 234 245
ESWL 20 27
Capsule endoscopy 26 34
Enteroscopy 71 72
Fibroscan 11243 15654
HVPG 1860 1950
TJLB 450 480
Cholangioscopy 6 7
Regeneration and stem cell therapy 59 69
Nutrition counselling 3499 3646
Body Composition Analysis 1000 1113

New services & facilities

  • Plasmapheresis and highvolume plasma exchange: Plasmapheresis  is the removal, treatment, and return or exchange of blood plasma or components thereof from and to the blood circulation. Removing blood plasma and exchanging it with blood products to be donated to the recipient. In  plasma exchange ,the removed plasma is discarded and the patient receives replacement donor plasma, albumin, or a combination of albumin and saline (usually 70% albumin and 30% saline). Plasmapheresis and plasma exchange can be used at therapeutic modality for various syndrome of liver failure like acute liver failue, acute on chronic liver failure, post resection liver failure.
  • Ultrasound Chest: A chest ultrasound is  used to assess the organs and structures within the chest, such as the lungs, mediastinum (area in the chest containing the heart, aorta, trachea, esophagus, thymus, and lymph nodes), and pleural space (space between the lungs and the interior wall of the chest). Ultrasound chest is being routinely used in management of patients at ILBS.
  • Gastric Balloon placement for obesity : For morbid obese patients one of the option is endoscopic placement of gastric balloon.The gastric balloon consists of soft, well-tolerated silicone that is filled with a sterile saline solution (salt water). The filled gastric balloon creates a sense of satiety. The balloon is generally removed after a maximum  of six months.
gast

 

  • EUS guided gastric varix coil embolization: Large gastric varices may some time be difficult to manage using direct endocopic glue injection. EUS guided coil and glue injection in gastric varices is a safe and alternative procedure to Radiological procedures like BRTO and direct endoscopic glue injection.
firoscan

EDUCATIONAL ACTIVITIES:

  • World Hepatitis Day - 2016: 28 July 2016
  • WHO Collaborative Center Work Review Meeting: 30 July 2016
  • ECHO-ILBS collaborative programme and Delhi Hepatitis Day: 4 Dec 2016
  • 1st National Conference on Critical Care and Infections in Liver

Diseases: 24-26 Jan 2017

 

  • The First National Conference of the Indian Society of Clinical Nutrition (INSCN) was jointly organized by the Department of Clinical Nutrition, Institute of Liver and Biliary Sciences, and the Indian Society of Clinical Nutrition at the APJ Abdul Kalam Auditorium, at ILBS, New Delhi. 14th -16th of October, 2016

 

Project ILBS Echo

Project ECHO (Extension for Community Healthcare Outcomes) is an innovative new model of health care education and delivery in New Mexico, USA which addresses the challenges of providing specialist level care in non metro settings. ILBS was first to replicate this model in India in 2012. The main objective of Projective ILBS-ECO is to develop capacity for safe and effective treatment of complex diseases in rural and semi-urban India and to identify, treat and manage liver related disorders across the
country.

Using state-of-the-art tele-health technology and clinical management tools ILBSECHO trains and supports physicians in the community to develop knowledge and self eficacy on a variety of liver diseases. Project ILBS-ECHO is not a traditional tele health model of one-to-one connection between a doctor and a patient using technology. It builds new and permanent capacities by developing specialist expertise where it
previously did not exist. It is not one to one, but one to many. ILBS ECHO session are conducted regularly at 2nd and Last Tuesday of every month, 3.30 pm where subject specialists give brief presentation and Cases are being presented by participating doctors . Till now, ILBS ECHO has conducted 44 sessions on HCV and Liver Diseases till date. At one time, roughly 8-10 doctors participate in a session. In 2016, we are aiming to implement ILBS-ECHO program across 25 Centers including Institute of Liver & Biliary Sciences, New Delhi medical colleges and more than 100 doctors with regular Updates, interactions, evaluation of Knowledge and certification.

Endoscopy Pathshala 2015, 22nd - 23rd August 2015

An Endoscopy pathshala was conducted in month of August by Department of Hepatology where the latest techniques and procedures were demonstrated by leading Gastroenterologists and Endoscopists from all over India. There was live demonstration of Endoscopic Glue injection, EUS guided FNAC, demonstration of
Cholangioscopy with LASER lithotripsy as well as demonstration of IDUS (Intraductal ultrasound) in biliary tree.

 

APASL Working party on ACLF

The Acute on Chronic Liver Failure is the new area of research with a rapid surge in number of publications across the globe. The APASL is the first to bring this concept into existence with its first consensus in 2009 followed by the recent one in 2014. The APASL ACLF Research - Consortium (AARC) is the forum for united approach to address the basic & clinical research, globally accepted definition and many more in future. ILBS conducted 12 video conferences to be in constant touch with collaborative investigator and for constant input and feedback. The Asian Network was widened with 24 centers across the Asia Pacific from i.e. Armenia, Bangladesh, China, Egypt, Hong Kong, India, Indonesia, Malaysia, Pakistan, Philippines, Republic of Korea, Singapore with nearly 2,200 patients enrolled from all over.

 

Courses Offered

 
Names of the Course Number of Candidates
admitted Year 2015
Number of Candidates
Passed Out Year 2015
DM Hepatology 04 04

 

ILBS has trained the following candidates till now

  • Dr Manisha Thakur ,Department of Medicine, Safdarjung Hospital, New Delhi
  • Dr Mohammad Faiz Ahmed Khondaker from Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh
  • Dr. Ahmed Lutful Moben, Shaheed, Suhrawardy Medical College & Hospital,Dhaka, Bangladesh
  • Dr Mohamed Adel Abdo Elbasiony , Faculty of Medicine, Mansoura University,Egypt
  • Dr Ignita Murty, Indonesia
  • Dr Hussein Abed El Latif, Mansoura University, Egypt
  • Dr. Seikh Mohammad Noor-E-Alam,Shaheed Suhrawardy Medical College and Hospital, Dhaka, Bangladesh.
 
  • ECHO
  • ECHO
  • APASL
  • Acuteon
  • DORSO
  • NSI
  • HBSCE

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