Advances in genomic analyses using high throughput technologies has resulted in a comprehensive understanding of the underlying pathobiological process associated with liver disease. Using sophisticated next-generation sequencing (NGS) technologies we have analysed involvement of micro RNA and gene expression in pregnant females with hepatitis E infection.
Hepatitis E is known to be more serious with fatal acute liver failure (FALF) and death in 15-20% of infected pregnant females. Integration of Small RNA deep sequencing and microarray analysis was helpful in identifying putative miRNA signatures indicative of fatal acute liver failure and Survival in HEV infection in pregnancy. Furthermore, we were able to select a panel of micro RNAs specific to HEV infection and Liver Failure