15+ years in Preclinical Research in Experimental Hepatology, Laboratory Animal Science, Research Ethics & Translational Therapeutics.

• M.V.Sc. (Animal Biotechnology) – Hisar Agriculture University, Hisar, 2010
• B.V.Sc. & A.H. – Ranchi Veterinary College, BAU, Ranchi, 2008
• Federation of European Laboratory Animal Science Associations (FELASA) ‘C’ Certified -Laboratory Animal Science.

• International Council for Laboratory Animal Science - Asian Federation of Laboratory Animal Science Associations (ICLAS–AFLAS) Youth Progress Award 2025
• Influential Women in Science Recognition by Revvity International – 2026

Investigating pathobiological mechanisms of liver diseases and regeneration and developing therapeutic strategies using preclinical models.

Research Leadership

• 08+ National & International Collaborative Grants as PI/Co-PI, supported by DBT-BioRiDE, DBT-BIRAC, DST-SERB, ICMR, Indo-French CEFIPRA and Indo-Netherlands DBT–Global Star programmes.
• Coordinator, IAEC-ILBS.
• 15+ Expert/Committee/Auditor roles with national institutions including AIIMS, ICMR-NIMR, BRIC-THSTI, CSIR-IGIB, BRIC-NBRC, JNU and CCSEA-GOI.

Academic & Capacity-building Contribution

• 08+ Completed DM/PhD thesis as a Co-PI.
• 1000+ Researchers trained.
• 50+ Invited lectures, speaker/resource-person engagements, session chair & oral presentations at national and international scientific forums.

Scientific Expertise

• Liver Injury & Regeneration
• MASLD/MASH
• Hepatocellular Carcinoma (HCC)
• Hepatopulmonary Syndrome (HPS)
• Alcohol-Associated Liver Disease (ALD)
• In-vivo Imaging

In-Vivo Research  & Support Services:

• Technical expertise in Designing and implementation  of “Animal Care and Use programe” including ABSL3 as per national (CCSEA,MOFA&H, GOI) and international regulatory standards such as Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International, USA) , Good Laboratory Practices- Organisation for Economic Co-operation and Development (GLP-OECD), Federation of European Laboratory Animal Science Associations (FELASA), American Veterinary Medical Association (AVMA), Biosafety in Microbiological and Biomedical Laboratories (BMBL,CDC,NIH) and Institutional Biosafty Committee (IBSC-DBT,GOI) etc. for Biomedical research and Biosafty guidelines. 
• Breeding and Maintenance of SPF and Immunodeficient laboratory animals (Rodents,Rabbits,Zebrafish etc.) for biomedical research. 
• Expertised in Aseptic Rodent survival surgery such as Common Bile duct ligation (CBDL), 2/3rd Partial Hepatectomy, Caecal Ligation Puncture (sepsis model), Spleenectomy, Assisted Reproductive Techniques (Egg collection, Embryo transfer, ovariohysterectomy, Vasectomy etc.) & biomethodologies (Oral gavage, IP,SC,IV,IM,ID and blood collection , organ Perfusion and tissue collection) animal experimental procedures by applying 3Rs and veterinary care practices for ABSL2 and ABSL3.
• Expertised in Molecular Biology Techniques (RTPCR, Bioanalyzer, Gel Electrophoresis, Clonning etc), Cell Culture and Immune cell Isolation  and FACS, Immunihistochemistry,ELISA. etc.
• Expertised in Microscopy and In-vivo Imaging Techniques on Optical imaging Model Perkin Elmer IVIS LUMINA XRMS as well as  LAGO- Spectral Imaging Instrument, and micro-CT .
• Establishment of Pig research Facility.

Accreditation & Regulatory Compliance:

• Member and Co-ordinator of Institutional Animal Ethics Committee (IAEC).
• Regulatory Compliance for Pre-clinical Facility Establishment and Operation as per national and international rules and regulations (CPCSEA, 2018 & NRC 2011). 
• Laboratory Animal Transport/Import.

Name of the conf./course/training/workshop attended:

• Oral Presentation on “Jet Lag Mouse fed on high fat diet shows fatty liver changes associated and partly reversed when fed with Nicotinamide Riboside” in 11^th International Conference of Laboratory Animal Scientists’ Association (LASA), India, on “Advancements of 3R’s in Biomedical Research and Laboratory Animal Science and Welfare: International Perspectives” 6-8^th November,2023,IISC, Bangaluru.
• Oral Turbo Talk on “Triple humanized mouse model: Next generation tool for malaria research ” in the International Conference  on Vector Borne Diseaes (NAVBD)  at GOA University,15^th-17^th Feb,2023.
• Oral Presentation on “A Common Bile Duct Ligation (CBDL) induced mice model of Hepato-Pulmonary syndrome (HPS).” in 10^th International Conference of Laboratory Animal Scientists’ Association (LASA), India, on “Animal Models for One Health Programme: Challenges and Future Perspectives” 3-4^th June 2022 at NAARM Hydrabad
• Participated in certificate course of One week training in “Mouse Microinjection and CRISPER/CAS” held at National Centre for Biological Scineces (NCBS), Bangalore, India, Oct 21^st-25^th, 2019.
• Participated in “IACUC/IAEC training: The AAALAC International Perspective” organized by ACTREC, Navi Mumbai (Oct-2015).
• Undergone Certification FELASA ‘C’  “Certificate Course in Laboratory Animal Sciences” of 80 Credit Hrs under the Mentorship of FELASA Congress Chairperson Dr. Patri Vergara held at TANUVAS jointly organized by NIAW,CPCSEA and LASA from 14^th - 23^rd September 2013 in Chennai, TN.
• Participated in  “One Week Training of CPCSEA Nominee” at NIAW, Ballabhgarh, Faridabad (Jan 2015).
• Undergone One Month Training in “Advance Training in Care, Breeding, Management, Health monitoring and Quality Control of Laboratory Animals” from 9th December 2011 to 8^th January 2012 at NLAC, CDRI, Lucknow.

Conferences and Invited Lectures:

• Organizing Secretary of  Four days Hands-on Workshop on “Basic Training in Animal Handling and Experimentation organized from last five years on 1^st- 4^th Novemeber-2023, 2^nd -5^th November-2022, 27^th  -30^th July-2021, 17^th -20^th Feb-2020 and  10^th -13^th July ,2019  at ILBS, New Delhi.
• Organizing Secretary of ‘Rodent Surgery Workshop’ organized on 1-3^rd June, 2023 and 25^th-27^th April,2024  at ILBS, New Delhi.
• Imparted Training and Lecture  in One week Workshop on “Workshop for Handling and Care of Laboratory Animals” on  28^th Nov-2^nd December,2023, 14^th-17^th Nov,2022 & 20-24^th Feb,2022 at JNU,New Delhi as a Resource Faculty  Member.
• Invited Lecture on “Refinement in Rodent Survival Surgery and Terminal Procedures” and imparted training as a Resource Faculty Member on “Aseptic Rodent Survival Surgery” in TPLAS, 27^th Oct-2^nd November, 2023 organized by Dept.of Pharmacy, BITS, Pillani Rajasthan.
• Imparted Training as a Resource Faculty Member in “Two weeks Certificate Course on  Laboratory Animal Sciences” from  6-17^th Feb 2023 at NBRC. Manesar, Haryana.
• Invited Speaker and Resource Person in "National Workshop on Animal Biosafety Level-2 (ABSL-2) practices" from 16th-17th May, 2022 at Jamia  Hamdard, New delhi.
• Invited Lecture on “Euthanasia and Necropsy Procedure in Lab Animal Experimentations” imparted training as a Resource Faculty Member in 5^th Course on Lab Animal Sciences (CLAS),  11^th-16^th April, 2024 organized by   IGIB, New Delhi.

Selected Publications- (Total- 25+)

• “Aspirin Reprograms Platelet Signaling and the Intrahepatic Microbiome to Suppress RyR2-Driven Inflammation and Fibrosis in Preclinical Chronic Liver Disease” Adil Bhat, Anupma Kumari, Sudishti Chaudhary, Shvetank Sharma, Shiv K Sarin JS Maras. Biomedicine & Pharmacotherapy. Biomedicine & Pharmacotherapy,2006. Vol- 198 (2026) 119296. Pg-1-16 https://doi.org/10.1016/j.biopha.2026.119296 [IF-7.5].
• “Plasma metabolomics identifies trimethylamine N-oxide as an accelerator of gallstone disease accompained by early neoplastic alterations in mice. V Yadav, D Sharma,V Yadav, Ragini Kilambi, N Mohapatra,A Bhardwaj, N.S Patil,S Sastrukar, A Rastogi,G Bhatia, A Kumari, P Nagarajan, K Agarwal, J S Maras, N Trehanpati , V Pamecha, Shiv K Sarin and G Ramakrishna.APJ Gastrointestinal and Liver Physiology, 2026. Vol 331, issue-2 pg-140-155, https://doi.org/10.1152/ajpgi.00413.2025 [IF-3.0].
• “Doxorubicin-loaded outer membrane vesicles (OMVs) equipped with anti-EpCAM aptamer show enhanced targeting of HCC." Pushpa Yadav; Preedia Babu E; Ritu Khosla; Anupama Kumari; Chhagan Bihari; Sukriti Baweja; Riddhi Sharma; Gayatri Ramakrishna; Nuno Viegas; Shiv Kumar Sarin, Nirupma Trehanpati. Journal of Drug Delivery Science and Technology (22 March, 2026 Accepted). Volume 120, June 2026, 108266.pg 1-12. https://doi.org/10.1016/j.jddst.2026.108266. [IF-6.2]
• "NAFLD is epigenetically regulated through alterations in m6A methylation in the metabolic gene transcripts by FTO demethylase." Sunita Giri, Anupma Kumari, Vijay Kumar. The Indian Journal Medical Research, November 2025. Vlo 162(3):pg 380-388. (DOI: 10.25259/IJMR_945_2025).
• “Deciphering Cancer Evolution Through Genomic Profiling of Patient Derived Xenograft Together with Matched Primary Gallbladder Cancer.” V Yadav, Ragini Kilambi, A Rastogi, D Sharma, P Nagarajan, V Suroliya, A Bhattacharya, V Yadav, P Gautam, M Kashayp, M K Kashyap, V Garg , A Kumari, N Trehanpati, G Ramakrishna. Dig Dis Sci. 2025 Nov. doi: 10.1007/s10620-025-09471-4.[IF-2.9]
• “Circulating urobilinogen contributes to Inflammation, Intestinal Permeability and corticosteroid non-response in Severe Alcoholic Hepatitis.” Manisha Yadav, Abhishak Gupta, Babu Mathew, Gaurav Tripathi,Nishu Dalal,Neha Sharm,Pushpa Yadav,Gaurav Yadav, Rita Singh, Vasundhra Bindal,Rimsha Saif, Sanju Yadav, Nupur Sharma, Sushmita Pandey, Sadam H Bhat, Ravinder Singh,Jitender Kumar,Manish Kushwaha, Tahseen Khan,Narendra Kumar Sharma, Ashima Bhaskar, Ved Prakash Dwivedi, Anil Kumar, Niraj Kumar,Dinesh Mani Tripathi, Nirupama Trehanpati, Anupama kumari, Shvetank Sharma,Shiv Kumar Sarin, Jaswinder Singh Maras. Molecular Therapy, 2025. https://doi.org/10.1016/j.ymthe.2025.06.041 [IF-11.249]
• “In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model.” Nupur Sharma, Sadam H. Bhat, Shweta Chaudhary, Babu Mathew, Sushmita Pandey, Sanju Yadav, Manisha Yadav, Vasundhra Bindal, Gaurav Tripathi, Neha Sharma, Vipul Sharma, Abhishak Gupta, Ranjan Nanda, Anupama Kumari, Shvetank Sharma, Jaswinder Singh Maras . Redox Biology, 2025.https://doi.org/10.1016/j.redox.2025.103674. [ IF-11.9]
• “Protein supplementation differentially alters gut microbiota and associated liver injury recovery in mouse model of alcohol-related liver disease.” Ashi Mittal, Nishu Choudhary, Anupama Kumari, KavitaYadav, JS Maras, SK. Sarin, Shvetank Sharm. Clinical Nutrition. 2025, Volume 46, Pages 96-106. DOI: 10.1016/j.clnu.2025.01.022. [IF-6.6].
• “Ethanol with thioacetamide murine model of alcoholic liver disease identifies pathways as targets for human disease.” Ashi Mittal, Nishu Choudhary, Sudrishti Chaudhary, Anupama Kumari , Archana Rastogi, Guresh Kumar ,Jaswinder Singh Maras , Shiv K Sarin , Shvetank Sharma. Annals of Hepatology 2025, Vol-30, Issue1, 101565. https://doi.org/10.1016/j.aohep.2024.101565. [IF-3.7]
• “Fingolimod In HPS: Assess and Then Judge, a Potential Ray of Hope.” Sukriti Baweja, Chhagan Bihari, Anupama Kumari, Dinesh Mani Tripathi, Shiv Kumar Sarin; Journal of Hepatology. Volume 79, Issue 5, November 2023, Pages e196-e197.DOI: 10.1016/j.jhep.2023.07.024. . [IF- 40.0]
• “Lipopolymeric nanocarrier enables effective delivery of CRISPR/Cas9 expressing plasmid.” Deepak Kumar Sahel, Sangam Giri Goswami, Reena Jatyan, Anupma Kumari, Anupama Mittal, Sivaprakash Ramalingam and Deepak Chitkara;Macromolecular Rapid Communications,Vol44:Issue 14. DOI:10.1002/marc.202300101.[ IF-5.006]
• “Hepatopulmonay syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod.” Sukriti Baweja, Anupama Kumari, Preeti Negi, Arvind Tomar, Dinesh Mani Tripathi, Akash Kumar Mourya, Aayushi Rastogi, Swati Thangariyal, P. Debishree Subudhi, Shivani Gautam, Ashmit Mittal, Guresh Kumar, Jitendra Kumar, G. Srinivasa Reddy, Arun Kumar Sood, Chitranshu Vashistha, Vivek Sarohi, Chhagan Bihari, Rakhi Maiwall, Shiv Kumar Sarin; Journal of Hepatology, Volume 79, Issue 1, July 2023, Pages 167-180. DOI:10.1016/j.jhep.2023.03.018.[IF- 40.0]
• “Vascular Extracellular Vesicles Indicate Severe Hepatopulmonary Syndrome in Cirrhosis.” Sukriti Baweja, Anupama Kumari, Preeti Negi, Swati Thangariyal, P. Debishree Subudhi, Shivani Gautam, Ashmit Mittal and Chhagan Bihari; Diagnostics 2023, 13(7), 1272; pg 1-11. 10.3390/ diagnostics 13071272. [IF -4.129].
• “Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH.” Tripathi DM, Rohilla S, Kaur I, Siddiqui H, Rawal P, Juneja P, Kumar V, Kumari A, Naidu VGM, Ramakrishna S, Banerjee S, Puria R, Sarin SK, Kaur S; Int J Mol Sci. 2021 Aug 6;22(16):8489. [IF-6.208]
• “Circulating Microvesicle Induced Monocyte Dysfunction Is Associated With Sepsis And High Mortality In Cirrhosis.” Sukriti S, Bihari C, Negi P, ThangariyalS, Kumari A, Lal D, Maheshwari D, , Singh MJ, Nautiyal N, Kumar G, Kumar A, Trehanpati N, Mehta G, Chaudhary AK^, Maiwal R, Sarin SK; Liver Int.2021 Jul;41(7):1614-1628.10.1111/liv.14875 [IF-8.754]
• “Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction.” Nautiyal N, Maheshwari D,Tripathi DM, Kumar D, Kumari R, Gupta S, Sharma S, Mohanty S, Parasar A, Bihari C, Biswas S, Rastogi A, Maiwall R, Kumar A, Sarin SK;Hepatol Int .2021 Dec; 15(6):1389-1401.10.1007/s12072-021-10244-0. [IF-9.046].

Book Chapter-

Book Chapter on “Animal Models in Cancer Research: Bridging the gap between Bench and Bedside”. Zaid Shaikh, Sakshi Anchan, Anupama Kumari and Rahul Thorat. Animal Models in Research: Principles and Practice, Publisher Springer Nature, ISBN-13 978-9819700479,1st edition 2024 (5th April,2024).